ChemicalBook > CAS DataBase List > 2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride

Product Name
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
CAS No.
587870-77-7
Chemical Name
2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride
Synonyms
ABT-724 (hydrochloride);ABT 724 trihydrochloride, 10 mM in DMSO;2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride;Inhibitor,Dopamine Receptor,penile,inhibit,potentiation,side-effect,ABT-724 trihydrochloride,Dopamine,D4-receptor,ABT 724 trihydrochloride,erection
CBNumber
CB92609611
Molecular Formula
C17H22Cl3N5
Formula Weight
402.74908
MOL File
587870-77-7.mol
More
Less

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Property

storage temp. 
2-8°C
solubility 
H2O: >30mg/mL
form 
powder
color 
white
Water Solubility 
Soluble to 100 mM in water
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A5111
Product name
ABT-724 trihydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$370
Updated
2025/07/31
Sigma-Aldrich
Product number
A5111
Product name
ABT-724 trihydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$107
Updated
2022/05/15
Cayman Chemical
Product number
29506
Product name
ABT-724 (hydrochloride)
Packaging
5mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
29506
Product name
ABT-724 (hydrochloride)
Packaging
10mg
Price
$87
Updated
2024/03/01
TRC
Product number
A112618
Product name
ABT-724 trihydrochloride
Packaging
1mg
Price
$100
Updated
2021/12/16
More
Less

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Chemical Properties,Usage,Production

Description

ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5. It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg. ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).

Uses

ABT-724 trihydrochloride is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

in vivo

ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats[1].

Animal Model:Male adult Wistar rats (~300 g)[1]
Dosage:8.8 μg/kg
Administration:Subcutaneous injection; daily; for 5 days
Result:Dose-dependently facilitated penile erection.

IC 50

D4 Receptor

storage

+4°C (desiccate)

References

[1]. sarkar c, das s, chakroborty d, et al. cutting edge: stimulation of dopamine d4 receptors induce t cell quiescence by up-regulating kruppel-like factor-2 expression through inhibition of erk1/erk2 phosphorylation. j immunol, 2006, 177(11):7525-9.
[2]. melis mr, succu s, mascia ms, et al. pd-168077, a selective dopamine d4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats. neurosci lett, 2005, 379(1):59-62.
[3]. sanna f, contini a, melis mr, et al. role of dopamine d4 receptors in copulatory behavior: studies with selective d4 agonists and antagonists in male rats. pharmacol biochem behav, 2015, 137:110-8.
[4]. arranz m, collier d, sodhi m, et al. association between clozapine response and allelic variation in 5-ht2a receptor gene. lancet, 1995, 346(8970):281-2.
[5]. boehmler w, carr t, thisse c, et al. d4 dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. genes brain behav, 2007, 6(2):155-66.

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochloride Suppliers

China 27 United Kingdom 1 United States 8 Global 36
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58

587870-77-7, 2-[[4-(2-Pyridinyl)-1-piperazinyl]Methyl]-1H-benziMidazole trihydrochlorideRelated Search:


  • 2-((4-(Pyridin-2-yl)piperazin-1-yl)methyl)-1H-benzo[d]imidazole trihydrochloride
  • ABT-724 (hydrochloride)
  • Inhibitor,Dopamine Receptor,penile,inhibit,potentiation,side-effect,ABT-724 trihydrochloride,Dopamine,D4-receptor,ABT 724 trihydrochloride,erection
  • ABT 724 trihydrochloride, 10 mM in DMSO
  • 587870-77-7