1,1-Dibromoformaldoxime
- Product Name
- 1,1-Dibromoformaldoxime
- CAS No.
- 74213-24-4
- Chemical Name
- 1,1-Dibromoformaldoxime
- Synonyms
- hydroxycarbonimidic dibromide;DIBROMOFORMALDOXIME;dibromomethanone oxime;broMonitrile oxide;74213-24-4;1,1-DibromoformaL;1-Dibromoformaldoxime;1,1-DIBROMOFORMALDOXIME;Pyroxasulfone Impurity 2;1,1-Dibromoformaldoxime,95%
- CBNumber
- CB9261253
- Molecular Formula
- CHBr2NO
- Formula Weight
- 202.83
- MOL File
- 74213-24-4.mol
1,1-Dibromoformaldoxime Property
- Melting point:
- 65-68 °C
- Boiling point:
- 230.0±23.0 °C(Predicted)
- Density
- 2.70±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Very Slightly, Heated), Methanol
- form
- Solid
- pka
- 7.52±0.11(Predicted)
- color
- White to Dark Orange
- InChI
- InChI=1S/CHBr2NO/c2-1(3)4-5/h5H
- InChIKey
- AWBKQZSYNWLCMW-UHFFFAOYSA-N
- SMILES
- C(/Br)(\Br)=N/O
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- D425300
- Product name
- Dibromoformaldoxime
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D425300
- Product name
- Dibromoformaldoxime
- Packaging
- 10g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- D2176
- Product name
- Dibromoformaldoxime
- Purity
- 96%+
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- BP-21275
- Product name
- 1,1-DIBROMOFORMALDOXIME
- Packaging
- 500mg
- Price
- $28
- Updated
- 2021/12/16
- Product number
- D2176
- Product name
- Dibromoformaldoxime
- Purity
- 96%+
- Packaging
- 5g
- Price
- $35
- Updated
- 2021/12/16
1,1-Dibromoformaldoxime Chemical Properties,Usage,Production
Uses
Dibromoformaldoxime is a reagent that undergoes cycloaddition with alkynes to prepare substituted 3-bromo-isoxazoles in high yield.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 387, 1984 DOI: 10.1016/S0040-4039(00)99890-3
Synthesis
298-12-4
74213-24-4
General procedure for the synthesis of 1,1-dibromoformaldehyde oxime from 2-oxoacetic acid: hydroxylamine hydrochloride (10 mmol) was added to a stirred aqueous (50 mL) solution of glyoxalic acid (10 mmol), and the reaction mixture was stirred for 24 hours at room temperature. Subsequently, sodium bicarbonate (20 mmol) was slowly added, followed by dichloromethane (60 mL). Bromine (1 mL) was added dropwise to the well-stirred two-phase mixture at 6 °C for 20 min. After the addition of bromine, stirring of the reaction mixture was continued for 3 hours. Upon completion of the reaction, the organic layer was separated and the aqueous layer was extracted with dichloromethane (50 mL). The organic extracts were combined, dried with magnesium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized with hexane (50 mL) to give 1.60 g (81% yield) of a white crystal product with a melting point of 65-66 °C (literature value 19: 63-65 °C).
References
[1] Tetrahedron Letters, 2015, vol. 56, # 13, p. 1635 - 1637
[2] EJNMMI Research, 2018, vol. 8,
[3] Angewandte Chemie - International Edition, 2017, vol. 56, # 13, p. 3703 - 3707
[4] Angew. Chem., 2017, vol. 129, # 13, p. 3757 - 3761,5
[5] Patent: WO2010/127978, 2010, A1. Location in patent: Page/Page column 51
1,1-Dibromoformaldoxime Preparation Products And Raw materials
Raw materials
Preparation Products
1,1-Dibromoformaldoxime Suppliers
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61
View Lastest Price from 1,1-Dibromoformaldoxime manufacturers
- Product
- 1,1-Dibromoformaldoxime 74213-24-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1,1-Dibromoformaldoxime 74213-24-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 657
- Release date
- 2019-09-01