1,3-Benzodioxol-5-aMine, 6-iodo-
- Product Name
- 1,3-Benzodioxol-5-aMine, 6-iodo-
- CAS No.
- 1000802-34-5
- Chemical Name
- 1,3-Benzodioxol-5-aMine, 6-iodo-
- Synonyms
- 5-Amino-6-iodo-1,3-benzodioxole; 6-Iodo-1,3-benzodioxol-5-amine;1,3-Benzodioxol-5-aMine, 6-iodo-;6-iodobenzo[d][1,3]dioxol-5-aMine;6-Iodo-benzo[1,3]dioxol-5-ylamine
- CBNumber
- CB92614518
- Molecular Formula
- C7H6INO2
- Formula Weight
- 263.03
- MOL File
- 1000802-34-5.mol
1,3-Benzodioxol-5-aMine, 6-iodo- Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Light yellow to brown Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AK127270
- Product name
- 6-Iodobenzo[d][1,3]dioxol-5-amine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $64
- Updated
- 2021/12/16
- Product number
- OR370010
- Product name
- 6-Iodobenzo[d][1,3]dioxol-5-amine
- Packaging
- 250mg
- Price
- $387
- Updated
- 2021/12/16
- Product number
- HCH0368137
- Product name
- 6-IODOBENZO[D][1,3]DIOXOL-5-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.03
- Updated
- 2021/12/16
- Product number
- A232480
- Product name
- 6-Iodobenzo[d][1,3]dioxol-5-amine
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- A232480
- Product name
- 6-Iodobenzo[d][1,3]dioxol-5-amine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $113
- Updated
- 2021/12/16
1,3-Benzodioxol-5-aMine, 6-iodo- Chemical Properties,Usage,Production
Synthesis
1000802-33-4
1000802-34-5
N-(6-Iodobenzo[d][1,3]dioxol-5-yl)acetamide (200 mg, 0.656 mmol) was used as a raw material, which was dissolved with NaOH (1.31 g, 32.8 mmol) in a solvent mixture of ethanol (26 mL) and water (6 mL). The reaction mixture was heated to reflux under stirring and kept for 4 hours. Upon completion of the reaction, the mixture was cooled and the solvent was evaporated under reduced pressure. The residue was extracted by partitioning with dichloromethane (100 mL) and water (100 mL). The organic layer was separated and washed with distilled water (2 x 100 mL). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford 6-iodobenzo[d][1,3]dioxol-5-amine (170 mg, 98% yield) as an orange solid. The product was analyzed by LC-MS showing [M+1]+ m/z 264; 1H NMR (DMSO-d6) δ 4.88 (s, 2H), 5.87 (s, 2H), 6.47 (s, 1H), 7.07 (s, 1H).
References
[1] Patent: US2008/234314, 2008, A1. Location in patent: Page/Page column 59
[2] Patent: US2010/184801, 2010, A1
[3] Patent: US2016/317508, 2016, A1. Location in patent: Paragraph 0181
[4] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 56
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 9, p. 3922 - 3943
1,3-Benzodioxol-5-aMine, 6-iodo- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,3-Benzodioxol-5-aMine, 6-iodo- manufacturers
- Product
- 6-Iodo-1,3-benzodioxol-5-amine 1000802-34-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-05