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EPZ004777

Product Name
EPZ004777
CAS No.
1338466-77-5
Chemical Name
EPZ004777
Synonyms
PEZ4777;CS-1932;EPZ 4777;EPZ-4777;EPZ004777;EPZ004777 USP/EP/BP;EPZ 004777;EPZ-004777;EPZ004777 (formic acid salt);DOT1L Inhibitor EPZ004777 EPZ-004777;EPZ004777; EPZ 004777; EPZ-004777;PEZ4777;EPZ 4777;EPZ-4777
CBNumber
CB92614846
Molecular Formula
C28H41N7O4
Formula Weight
539.67
MOL File
1338466-77-5.mol
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EPZ004777 Property

Boiling point:
740.7±60.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥27 mg/mL in DMSO; insoluble in H2O; ≥94.6 mg/mL in EtOH with ultrasonic
form 
solid
pka
12.51±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16173
Product name
EPZ004777 (formic acid salt)
Purity
≥98%
Packaging
500μg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
16173
Product name
EPZ004777 (formic acid salt)
Purity
≥98%
Packaging
1mg
Price
$45
Updated
2021/12/16
Cayman Chemical
Product number
16173
Product name
EPZ004777 (formic acid salt)
Purity
≥98%
Packaging
5mg
Price
$180
Updated
2021/12/16
Cayman Chemical
Product number
16173
Product name
EPZ004777 (formic acid salt)
Purity
≥98%
Packaging
10mg
Price
$235
Updated
2021/12/16
Tocris
Product number
5567
Product name
EPZ004777
Purity
≥98%(HPLC)
Packaging
10
Price
$279
Updated
2021/12/16
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EPZ004777 Chemical Properties,Usage,Production

Uses

EPZ 004777 is potent small molecule inhibitor of protein lysine methyltransferase DOT1L.

Definition

ChEBI: 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-7-pyrrolo[2,3-d]pyrimidinyl)-3,4-dihydroxy-2-oxolanyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea is a N-glycosyl compound.

Biological Activity

epz004777 is a specific small-molecule h3k79 methyltransferase dot1l inhibitor that potently inhibits dot1l in a radionuclide homogeneous assay with the half maximal inhibition concentration ic50 value of 400 pm and selectively kills a variety of mll-rearranged leukemia cells, including an mll-af4 leukemia cell line mv4-11 and an mll-af9 leukemia cell line molm13 [1 & 2].epz004777 has also been found to selectively inhibit the proliferation of mll-af10 and calm-af10 transformed cells in a dose dependent manner (ic50: 0.1 μm to 1 μm), in which the mrna expression levels of two hallmark leukemogenic genes (hoxa9 and meis1) are suppressed by epz004777 in a concentration dependent manner [2].

storage

Store at -20°C

EPZ004777 Preparation Products And Raw materials

Raw materials

Preparation Products

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EPZ004777 Suppliers

China 100 France 1 India 2 United Kingdom 1 United States 15 Global 119
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from EPZ004777 manufacturers

Career Henan Chemical Co
Product
EPZ004777 1338466-77-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-02

1338466-77-5, EPZ004777Related Search:

EPZ015666 1-Cyclopentyl-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-6-(4-(MorpholinoMethyl)phenyl)-1H-indazole-4-carboxaMide Bortezomib SB 431542 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol SGC0946 Dabrafenib Ibrutinib

  • 1-(3-((((2R,3S,4R,5R)-5-(4-AMino-7H-pyrrolo[2,3-d]pyriMidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)Methyl)(isopropyl)aMino)propyl)-3-(4-(tert-butyl)phenyl)urea
  • 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-
  • 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine EPZ 004777
  • EPZ 004777 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran
  • EPZ004777
  • 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • EPZ004777 (formic acid salt)
  • 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • EPZ 4777
  • EPZ004777; EPZ 004777; EPZ-004777;PEZ4777;EPZ 4777;EPZ-4777
  • EPZ-4777
  • PEZ4777
  • CS-1932
  • EPZ 004777;EPZ-004777
  • 7-(5-Deoxy-5-{isopropyl[3-({[4-(2-methyl-2-propanyl)phenyl]carbamoyl}amino)propyl]amino}-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • EPZ004777 USP/EP/BP
  • 1-[3-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea
  • DOT1L Inhibitor EPZ004777 EPZ-004777
  • 1338466-77-5
  • C28H41N7O4
  • Inhibitors