Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
- Product Name
- Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
- CAS No.
- 17366-48-2
- Chemical Name
- Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride
- Synonyms
- Nortropine Impurity;Nortropine Impurity 1 HCl;Nortropine Impurity 2 HCl;Exo-3-hydroxy-8-azabicycl...;EXO-3-HYDROXY-8-AZABICYCLO[3.2.1]OCTANE HCL;exo-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride;(3-exo)-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride;Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride;rel-(1R,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride;8-Azabicyclo[3.2.1]octan-3-ol, hydrochloride (1:1), (3-exo)-
- CBNumber
- CB92615292
- Molecular Formula
- C7H14ClNO
- Formula Weight
- 163.64516
- MOL File
- 17366-48-2.mol
Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Property
- Melting point:
- 200 °C
- storage temp.
- Inert atmosphere,Room Temperature
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H313May be harmful in contact with skin
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0049365
- Product name
- exo-3-Hydroxy-8-azabicyclo[3.2.1]octanehydrochloride
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 112099
- Product name
- exo-3-Hydroxy-8-azabicyclo-[3.2.1]octane hydrochloride
- Packaging
- 1g
- Price
- $227
- Updated
- 2021/12/16
- Product number
- 3938CZ
- Product name
- Exo-3-hydroxy-8-azabicyclo[3.2.1]octanehydrochloride
- Packaging
- 1g
- Price
- $231
- Updated
- 2021/12/16
- Product number
- CS-0049365
- Product name
- exo-3-Hydroxy-8-azabicyclo[3.2.1]octanehydrochloride
- Packaging
- 5g
- Price
- $473
- Updated
- 2021/12/16
- Product number
- 112099
- Product name
- exo-3-Hydroxy-8-azabicyclo-[3.2.1]octane hydrochloride
- Packaging
- 5g
- Price
- $607
- Updated
- 2021/12/16
Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Chemical Properties,Usage,Production
Synthesis
194222-05-4
17366-48-2
Step 1. Preparation of (1R,3S,5S)-8-azabicyclo[3.2.1]octan-3-ol hydrochloride: tert-butyl (1R,3S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate (300 mg, 1.32 mmol) was dissolved in a solution of 1,4-dioxane (4.0 mL) in 4 M HCl and the reaction was stirred at room temperature for 15 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to give the target product (168 mg, quantitative yield) as a white solid, which could be used in subsequent steps without further purification.LC-MS analysis: calculated value 127.1 [M + H]+, measured value 127.90 [M + H]+.
References
[1] Patent: US2012/53180, 2012, A1. Location in patent: Page/Page column 35
[2] Patent: WO2013/61305, 2013, A1. Location in patent: Page/Page column 44
Exo-3-hydroxy-8-azabicyclo[3.2.1]octane hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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