ENMD-2076 (Tartrate)

ChemicalBook > CAS DataBase List > ENMD-2076 (Tartrate)

Product Name: ENMD-2076 (Tartrate)
CAS No.: 1291074-87-7
Chemical Name: ENMD-2076 (Tartrate)
Synonyms: ENMD-2076 (Tartrate);ENMD-2076 L-(+)-Tartaric acid;ENMD-2076 tartrate (ENMD 2076;(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine,L-(+)-Tartaric acid
CBNumber: CB92624137
Molecular Formula: C21H25N7.x(C4H6O6)
Formula Weight: 0
MOL File: Mol file

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ENMD-2076 (Tartrate) Property

storage temp.: Store at -20°C
solubility: insoluble in EtOH; ≥175.8 mg/mL in DMSO
form: solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A4129
Product name: ENMD-2076L-(+)-Tartaricacid
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0210
Product name: ENMD-2076Tartrate
Purity: 98.87%
Packaging: 5mg
Price: $120
Updated: 2021/12/16

ApexBio Technology

Product number: A4129
Product name: ENMD-2076L-(+)-Tartaricacid
Packaging: 50mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0210
Product name: ENMD-2076Tartrate
Purity: 98.87%
Packaging: 10mg
Price: $180
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611816
Product name: ENMD-2076 tartrate
Packaging: 10mg
Price: $210.8
Updated: 2021/12/16

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ENMD-2076 (Tartrate) Chemical Properties,Usage,Production

Uses

ENMD-2076 (ENMD-981693, ENMD2076) is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1.

Biological Activity

enmd-2076 is an orally bioavailable, small molecule inhibitor of aurora kinases with ic50 values of 14nm and 350nm, respectively against aurora kinase a and aurora kinase b [1].besides aurora kinases, enmd-2076 inhibits multiple kinases involved in various cellular activities. overexpression of aurora kinase a has been found in breast cancers and enmd-2076 is thereby studied in breast cancers. it is reported that enmd-2076 differentially inhibits 29 breast cancer cell lines with ic50 values ranged from 0.25 to 16.1μm. in the clonogenic assays, enmd-2076 totally suppresses the colony formation in the sensitivemda-mb-468 cell line and decreases the formation in thehcc1806, sk-br-3, and bt474 cell lines. enmd-2076 is also reported to cause a g2 cell-cycle arrest at 1.25μm. moreover, enmd-2076 shows antitumor activity in tnbc xenograft models. apart from the breast cancers, enmd-2076 is developed in hematological malignancies therapy. the

References

[1] diamond jr, eckhardt sg, tan ac, newton tp, selby hm, brunkow kl, kachaeva mi, varella-garcia m, pitts tm, bray mr, fletcher gc, tentler jj. predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor enmd-2076 in preclinical breast cancer models. clin cancer res. 2013 jan 1;19(1):291-303.
[2] how j, yee k. enmd-2076 for hematological malignancies. expert opin investig drugs. 2012 may;21(5):717-32.

ENMD-2076 (Tartrate) Preparation Products And Raw materials

Raw materials

Preparation Products

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1291074-87-7, ENMD-2076 (Tartrate)Related Search:

Alisertib (MLN8237)

(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine,L-(+)-Tartaric acid

ENMD-2076 (Tartrate)

ENMD-2076 L-(+)-Tartaric acid

ENMD-2076 tartrate (ENMD 2076

1291074-87-7

291074-87-7

C21H25N7xC4H6O6

C25H31N7O6

Inhibitors

Inhibitor