NBD-556
- Product Name
- NBD-556
- CAS No.
- 333353-44-9
- Chemical Name
- NBD-556
- Synonyms
- NBD-556;NBD-556;NBD 556; NBD556;N-(4-Chlorophenyl)-N'-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethylpiperidin-4-yl)oxalamide;N1-(4-Chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-ethanediamide;Ethanediamide, N1-(4-chlorophenyl)-N2-(2,2,6,6-tetramethyl-4-piperidinyl)-;inhibit,HIV-1,fusion,virus-cell,Human immunodeficiency virus,NBD556,HIV,Inhibitor,gp120,CD4,NBD 556,NBD-556,mimetic
- CBNumber
- CB92624263
- Molecular Formula
- C17H24ClN3O2
- Formula Weight
- 337.84
- MOL File
- 333353-44-9.mol
NBD-556 Property
- Density
- 1.20
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0812
- Product name
- NBD-556
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $95.2
- Updated
- 2024/03/01
- Product number
- SML0812
- Product name
- NBD-556
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $482
- Updated
- 2024/03/01
- Product number
- N1090
- Product name
- NBD-556
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $261
- Updated
- 2024/03/01
- Product number
- N1090
- Product name
- NBD-556
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $718
- Updated
- 2024/03/01
- Product number
- 21274
- Product name
- NBD-556
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
NBD-556 Chemical Properties,Usage,Production
Uses
NBD-556 is a N-phenyl-N''-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction.
Uses
NBD-556 is a N-phenyl-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide analog, a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors that block the gp120-CD4 interaction.
Biological Activity
the entry of hiv-1 into host cells is mediated by the binding of the surface subunit gp120 to the host cell receptor cd4. nbd-556 is a novel class of human immunodeficiency virus type 1 (hiv-1) entry inhibitor that block the gp120–cd4 interaction with drug-like properties.
in vitro
a systematic study showed that nbd-556 and nbd-557 target viral entry by inhibiting the binding of hiv-1 envelope glycoprotein gp120 to the cellular receptor cd4 but did not inhibit reverse transcriptase, protease, or integrase, demonstrating that they do not target the later stages of the hiv-1 life cycle to inhibit hiv-1 infection. nbd-556 and nbd-557 were also active against hiv-1 laboratory-adapted strains including an azt-resistant strain and hiv-1 primary isolates, showing that these compounds can potentially be further modified to become potent hiv-1 entry inhibitors [1].
IC 50
nbd-556 inhibited cell–cell fusion between h9/hiv-1iiib and mt-2 (ic50 ~3 μm)
References
[1] zhao, q. , l. ma, s. jiang, h. lu, s. liu, y. he, n. strick, n. neamati, and a. k. debnath. 2005. identification of n-phenyl-n′-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamides as a new class of hiv-1 entry inhibitors that prevent gp120 binding to cd4. virology 339:213-225.
NBD-556 Preparation Products And Raw materials
Raw materials
Preparation Products
NBD-556 Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 94838
- Advantage
- 76
- Tel
- 021-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6011
- Advantage
- 61
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28398
- Advantage
- 80
- Tel
- 320-37350700
- Fax
- +32 (0)37350701
- sales@tcieurope.eu
- Country
- Europe
- ProdList
- 23680
- Advantage
- 75
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23662
- Advantage
- 75
- Tel
- 18521735133 18521732826;
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25015
- Advantage
- 65
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- 13120367189
- Fax
- 021-50315529
- mychess007@163.com
- Country
- China
- ProdList
- 1994
- Advantage
- 55
- Tel
- +86-21-5821 5861
- Fax
- +86-21-5106 2861
- sales@letopharm.com
- Country
- China
- ProdList
- 2384
- Advantage
- 58