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Umeclidinium bromide

Product Name
Umeclidinium bromide
CAS No.
869113-09-7
Chemical Name
Umeclidinium bromide
Synonyms
CS-1562;UMeclidiuM;GSK573719A;Umeclidiniu;umeclidinium;Umecium bromide;Umeclinidium bromide;UMeclidiniuM broMide;Jmechlidinium bromide;Umeclidinium(GSK573719A)
CBNumber
CB92625301
Molecular Formula
C29H34BrNO2
Formula Weight
508.48976
MOL File
869113-09-7.mol
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Umeclidinium bromide Property

Melting point:
>231°C (dec.)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20700
Product name
Umeclidinium (bromide)
Purity
≥98%
Packaging
10mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
20700
Product name
Umeclidinium (bromide)
Purity
≥98%
Packaging
50mg
Price
$543
Updated
2024/03/01
Cayman Chemical
Product number
20700
Product name
Umeclidinium (bromide)
Purity
≥98%
Packaging
100mg
Price
$961
Updated
2024/03/01
TRC
Product number
U710000
Product name
UmeclidiniumBromide
Packaging
50mg
Price
$645
Updated
2021/12/16
Biosynth Carbosynth
Product number
FU65201
Product name
Umeclinidium bromide
Packaging
50mg
Price
$60
Updated
2021/12/16
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Umeclidinium bromide Chemical Properties,Usage,Production

Description

Umeclidinium bromide is a long-acting muscarinic acetylcholine antagonist developed by GlaxoSmithKline and approved by the US FDA at the end of 2013 for use in combination with vilanterol, a b2 agonist, for the treatment of chronic obstructive pulmonary disease. Due to umeclidinium’s poor oral bioavailability, the drug is administrated by inhalation as dry powder.

Uses

Umeclidinium Bromide is considered as a potentially long-acting antimuscarinic agent.

Definition

ChEBI: A quaternary ammonium salt that is the bromide salt of umeclidinium. Used in combination with vilanterol for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.

Synthesis

Commercially available ethyl isonipecotate (278) was alkylated with 1-bromo-2-chloroethane in the presence of K2CO3 in acetone to give ethyl 1-(2-chloroethyl)piperidine-4-carboxylate (279). This material was then treated with lithium diisopropylamine (LDA) in THF to affect a transannular substitution reaction resulting in the cyclized quinuclidine 280 in 96% yield. Excess of phenyllithium was added to ester 280 in THF starting at low temperature then gradually warming to room temperature to give tertiary alcohol 281 in 61% yield. Amine 281 was finally alkylated with benzyl 2- bromoethyl ether (282) in MeCN/CHCl3 at elevated temperatures to afford umeclidinium bromide (XXXV) in 69% yield.

References

[1] salmon m, luttmann m a, foley j j, et al. pharmacological characterization of gsk573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. journal of pharmacology and experimental therapeutics, 2013, 345(2): 260-270.

Umeclidinium bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Umeclidinium bromide manufacturers

Sinoway Industrial co., ltd.
Product
Umeclidinium Bromide 869113-09-7
Price
US $0.00-0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
0.99
Supply Ability
20 tons
Release date
2023-07-11
Baoji Guokang Bio-Technology Co., Ltd.
Product
Umeclidinium bromide 869113-09-7
Price
US $124.00/g
Min. Order
1g
Purity
99
Supply Ability
100KG
Release date
2021-06-04
Hebei Yanxi Chemical Co., Ltd.
Product
Umeclidinium bromide 869113-09-7
Price
US $100.00/kg
Min. Order
1kg
Purity
99% HPLC
Supply Ability
500KG/WEEK
Release date
2023-09-18

869113-09-7, Umeclidinium bromideRelated Search:

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  • High purity CAS 869113-09-7 Umeclidinium bromide in stock
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