ChemicalBook > CAS DataBase List > 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-

1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-

Product Name
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
CAS No.
467459-31-0
Chemical Name
1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
Synonyms
LU AE58054;LU AE58084;idalopirdine;LU AE58054(Idalopirdine);Idalopirdine(Lu-AE-58054);idalopirdine, 10 mM in DMSO;IDALOPIRDINE;LU AE 58054;LUAE58054;LU AE58054 HYDROCHLORIDE; LU AE 58054 HYDROCHLORIDE;N-[2-(6-Fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine;6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-Indole-3-ethanamine
CBNumber
CB92625336
Molecular Formula
C20H19F5N2O
Formula Weight
398.37
MOL File
467459-31-0.mol
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1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Property

Boiling point:
500.9±50.0 °C(Predicted)
Density 
1.309±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
25℃: DMSO
form 
Powder
pka
16.63±0.30(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3455
Product name
Idalopirdine
Purity
≥98% (HPLC)
Packaging
10 mg
Price
$56.81
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3455
Product name
Idalopirdine
Purity
≥98% (HPLC)
Packaging
50 mg
Price
$268
Updated
2025/07/31
Cayman Chemical
Product number
27335
Product name
LU AE58054
Packaging
100mg
Price
$547
Updated
2024/03/01
Cayman Chemical
Product number
27335
Product name
LU AE58054
Packaging
250mg
Price
$1139
Updated
2024/03/01
Cayman Chemical
Product number
27335
Product name
LU AE58054
Packaging
25mg
Price
$153
Updated
2024/03/01
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1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Chemical Properties,Usage,Production

Uses

The selective and high affinity 5-?HT6 receptor antagonist Lu AE58054 as promising treatment for cognitive disorders, in particular for Alzheimer’s disease (AD).

Biological Activity

Idalopirdine (Lu AE58054) is an orally available, and potent antagonist of the serotonin 6 (5-HT6) receptor. Idalopirdine has been reported to be highly selective over other G-protein coupled receptors. It has K(d) of 0.2nM for the 5-HT6 receptor with 16-fold selectivity over the 5-HT2A receptor (K(i) 3.2nM) and >100-fold selectivity to all other evaluated targets.

in vivo

Idalopirdine (intraperitoneal injection, 5?mg/kg, daily, 28 days) can reduce food intake and body weight in over-eating rat models[1].
Idalopirdine (1 or 2?mg/kg, i.v) can dose-dependently increase the gamma power during nPO electrical stimulation, enhance effect of donepezil on cortical gamma oscillations but no alteration of sleep-wake patterns in rats[2].

Animal Model:Male Wistar rats[1]
Dosage:5?mg/kg
Administration:intraperitoneal injection, daily, 28 days
Result:Significantly reduced the amount of calories consumed by animals in a palatable diet and significantly reduced plasma levels of glucose, triglycerides and cholesterol.
Animal Model:Male Sprague-Dawley rats[2]
Dosage:1 or 2?mg/kg
Administration:i.v.
Result:No significant increase in the gamma power at 1 mg/kg and significantly increased the gamma power at 2 mg/kg.
Significantly enhanced and/or prolonged effect of low-dose donepezil (0.3 mg/kg) on gamma power during 60-minute nPO stimulation after donepezil administration.

IC 50

5-HT6 Receptor: 0.83 nM (Ki)

1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- Suppliers

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Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]- manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Lu Ae58054 467459-31-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-13
Career Henan Chemical Co
Product
2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phen yl]methyl]ethanamine 467459-31-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23
Career Henan Chemical Co
Product
Lu AE58054 467459-31-0
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-20

467459-31-0, 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-Related Search:

LUTETIUM

  • LU AE58054
  • N-[2-(6-Fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine
  • 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-1H-Indole-3-ethanamine
  • idalopirdine
  • LU AE58084
  • LU AE58054(Idalopirdine)
  • 1H-Indole-3-ethanaMine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]Methyl]-
  • Idalopirdine(Lu-AE-58054)
  • LU AE58054 HYDROCHLORIDE; LU AE 58054 HYDROCHLORIDE
  • 2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phen yl]methyl]ethanamine
  • IDALOPIRDINE;LU AE 58054;LUAE58054
  • 5-HT Receptor,Serotonin Receptor,Lu AE-58054,idalopirdine,Inhibitor,inhibit,5-hydroxytryptamine Receptor,Lu AE 58054
  • idalopirdine, 10 mM in DMSO
  • 467459-31-0
  • C20H19F5N2O