DG 051 (HCl salt)

Product Name: DG 051 (HCl salt)
CAS No.: 929915-58-2
Chemical Name: DG 051 (HCl salt)
Synonyms: DG051;DG051 (DG-051;DG 051 (HCl salt);DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
CBNumber: CB92627754
Molecular Formula: C21H25Cl2NO4
Formula Weight: 426.3335
MOL File: 929915-58-2.mol

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DG 051 (HCl salt) Property

storage temp.: Store at -20°C
solubility: DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21688
Product name: DG-051
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21688
Product name: DG-051
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 21688
Product name: DG-051
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 21688
Product name: DG-051
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

TRC

Product number: C381365
Product name: (2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoicAcidHydrochloride
Packaging: 100mg
Price: $1365
Updated: 2021/12/16

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DG 051 (HCl salt) Chemical Properties,Usage,Production

Description

DG-051 is a potent, orally bioavailable leukotriene A₄ hydrolase (LTA₄H) inhibitor (K_d = 25 nM; IC₅₀ = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB₄ . However, it also inhibits the aminopeptidase activity of LTA₄H with IC₅₀ values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.

Uses

(2S)?-2-?[[4-?(4-Chlorophenoxy)?phenoxy]?methyl]?-1-?pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers.

DG 051 (HCl salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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DG 051 (HCl salt) Suppliers

China 30 India 1 United States 4 Global 35

Shanghai ChuangYan Chemical Technology Co., Ltd.

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Musechem

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Fan De(Beijing) Biotechnology Co., Ltd.

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DC Chemicals

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Chongqing Chemdad Co., Ltd

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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View Lastest Price from DG 051 (HCl salt) manufacturers

Career Henan Chemical Co

Product: DG 051 (HCl salt) 929915-58-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 96%
Supply Ability: 500kg
Release date: 2018-08-20

929915-58-2, DG 051 (HCl salt)Related Search:

DG 051 (HCl salt)

4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride

DG051

(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride

DG051 (DG-051

DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051

929915-58-2