ChemicalBook > CAS DataBase List > DG 051 (HCl salt)

DG 051 (HCl salt)

Product Name
DG 051 (HCl salt)
CAS No.
929915-58-2
Chemical Name
DG 051 (HCl salt)
Synonyms
DG051;DG051 (DG-051;DG 051 (HCl salt);DG051, 10 mM in DMSO;DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051;(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride;(S)-4-(2-((4-(4-Chlorophenoxy)phenoxy)methyl)pyrrolidin-1-yl)butanoic acid hydrochloride;4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
CBNumber
CB92627754
Molecular Formula
C21H25Cl2NO4
Formula Weight
426.3335
MOL File
929915-58-2.mol
More
Less

DG 051 (HCl salt) Property

storage temp. 
Store at -20°C
solubility 
DMF: 20 mg/ml; DMSO: 12.5 mg/ml; Ethanol: 12.5 mg/ml; PBS (pH 7.2): 2 mg/ml
form 
Solid
color 
White to light yellow
InChI
InChI=1/C21H24ClNO4.ClH/c22-16-5-7-19(8-6-16)27-20-11-9-18(10-12-20)26-15-17-3-1-13-23(17)14-2-4-21(24)25;/h5-12,17H,1-4,13-15H2,(H,24,25);1H/t17-;/s3
InChIKey
UCPVOTSNNAVKNE-VOPAOICTNA-N
SMILES
C(O)(=O)CCCN1CCC[C@H]1COC1=CC=C(OC2=CC=C(Cl)C=C2)C=C1.Cl |&1:10,r|
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21688
Product name
DG-051
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21688
Product name
DG-051
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21688
Product name
DG-051
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
21688
Product name
DG-051
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
TRC
Product number
C381365
Product name
(2S)​-2-​[[4-​(4-Chlorophenoxy)​phenoxy]​methyl]​-1-​pyrrolidinebutanoicAcidHydrochloride
Packaging
100mg
Price
$1365
Updated
2021/12/16
More
Less

DG 051 (HCl salt) Chemical Properties,Usage,Production

Description

DG-051 is a potent, orally bioavailable leukotriene A4 hydrolase (LTA4H) inhibitor (Kd = 25 nM; IC50 = 47 nM), the enzyme that catalyzes the rate-determining step in the synthesis of LTB4 . However, it also inhibits the aminopeptidase activity of LTA4H with IC50 values of 72 and 150 nM when tested using the substrates L-alanine p-nitroanaline and prolyl-glycyl-proline peptide (PGP; ), respectively, potentially leading to PGP accumulation in vivo. DG-051 does not show any inhibitory activity against a panel of more than 50 additional aminopeptidases, ion channels, or HERG.

Uses

(2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride is a potent inhibitor leukotriene A4 hydrolase (LTA4H), which is a therapeutic target for developing treatments for cardiovascular diseases and cancers.

References

[1] VINCENT SANDANAYAKA. Discovery of 4-[(2S)-2-{[4-(4-Chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic Acid (DG-051) as a Novel Leukotriene A4 Hydrolase Inhibitor of Leukotriene B4 Biosynthesis[J]. Journal of Medicinal Chemistry, 2009, 53 2: 573-585. DOI: 10.1021/jm900838g
[2] CAROLINE M LOW. The development of novel LTA4H modulators to selectively target LTB4 generation.[J]. Scientific Reports, 2017: 44449. DOI: 10.1038/srep44449

DG 051 (HCl salt) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DG 051 (HCl salt) Suppliers

China 38 India 1 United States 4 Global 43
Shanghai ChuangYan Chemical Technology Co., Ltd.
Tel
021-11111111 11111111111
Fax
qq:546919421
Email
546919421@qq.com
Country
China
ProdList
3662
Advantage
55
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Country
China
ProdList
16111
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
More
Less

View Lastest Price from DG 051 (HCl salt) manufacturers

Career Henan Chemical Co
Product
DG 051 (HCl salt) 929915-58-2
Price
US $1.00/KG
Min. Order
1KG
Purity
96%
Supply Ability
500kg
Release date
2018-08-20

929915-58-2, DG 051 (HCl salt)Related Search:


  • DG 051 (HCl salt)
  • 4-((S)-2-((4-(4-chlorophenoxy)phenoxy)Methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
  • DG051
  • (2S)-2-[[4-(4-Chlorophenoxy)phenoxy]methyl]-1-pyrrolidinebutanoic Acid Hydrochloride
  • DG051 (DG-051
  • DG051,Aminopeptidase,inhibit,DG 051,Inhibitor,DG-051
  • DG051, 10 mM in DMSO
  • (S)-4-(2-((4-(4-Chlorophenoxy)phenoxy)methyl)pyrrolidin-1-yl)butanoic acid hydrochloride
  • 929915-58-2