ChemicalBook > CAS DataBase List > SQ 109

SQ 109

Product Name
SQ 109
CAS No.
502487-67-4
Chemical Name
SQ 109
Synonyms
SQ 109;NSC 722041;Cenobamate;SQ109 (NSC 722041);SQ109 >=98% (HPLC);SQ109, 10 mM in DMSO;SQ 109; SQ-109; NSC 722041;N'-(2-adamantyl)-N-[(2E)-3,7-dimethylocta-2,6-dienyl]ethane-1,2-diamine;1,2-Ethanediamine,N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-;1,2-Ethanediamine,N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-
CBNumber
CB92628423
Molecular Formula
C22H38N2
Formula Weight
330.55
MOL File
502487-67-4.mol
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SQ 109 Property

Boiling point:
450.0±33.0 °C(Predicted)
Density 
0.97±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
oil
pka
9.80±0.20(Predicted)
color 
colorless to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1309
Product name
SQ109
Purity
≥98% (HPLC)
Packaging
10MG
Price
$326
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1309
Product name
SQ109
Purity
≥98% (HPLC)
Packaging
50MG
Price
$924
Updated
2025/07/31
ChemScene
Product number
CS-1188
Product name
SQ109
Purity
98.01%
Packaging
50mg
Price
$1195
Updated
2021/12/16
ChemScene
Product number
CS-1188
Product name
SQ109
Purity
98.01%
Packaging
100mg
Price
$1440
Updated
2021/12/16
ApexBio Technology
Product number
A3834
Product name
SQ109
Packaging
50mg
Price
$1460
Updated
2021/12/16
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SQ 109 Chemical Properties,Usage,Production

Uses

SQ109 has been used:

  • as an antitubercular?agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
  • as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis?(Mtb) using the resazurin microtiter assay (REMA) plate method
  • as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action

General Description

SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.

Biochem/physiol Actions

SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.

in vivo

Oral administration of SQ109 (0.1-25 mg/kg per day) to the mice for 28 days results in dose-dependent reductions of mycobacterial load in both spleen and lung comparable to that of EMB administered at 100 mg/kg per day, but is less potent than isoniazid (INH) at 25 mg/kg per day. Pharmacokinetic profiles of SQ109 in mice following a single administration showed its Cmax as 1038 (intravenous (i.v.)) and 135 ng/mL (p.o.), with an oral Tmax of 0.31 h. The elimination t1/2 of SQ109 is 3.5 (i.v.) and 5.2 h (p.o.). The oral bioavailability is 4%[2]. The terminal half-life (t1/2) of SQ109 in dogs (12-29 h, mean 29.3 h) is longer than in rats (7-8 h, mean 7.4 h), as reflected by the significantly larger volume of distribution of SQ109 in dogs. The oral bioavailability of SQ109 in rats and dogs is determined to be 12% and 5%, respectively[3].

target

Mycobacterium

IC 50

Trypanosoma

SQ 109 Preparation Products And Raw materials

Raw materials

Preparation Products

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SQ 109 Suppliers

China 92 India 3 United States 6 Global 101
ChemShuttle, Inc.
Tel
0510-83588313-811 18800520310
Email
sales@chemshuttle.com
Country
China
ProdList
2999
Advantage
62
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6468
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
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View Lastest Price from SQ 109 manufacturers

Guangzhou Tosun Pharmaceutical Ltd
Product
Cenobamate 502487-67-4
Price
US $0.00-0.00/kg
Min. Order
5kg
Purity
98%-102%
Supply Ability
200kg
Release date
2024-12-27
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Cenobamate
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-03-21
Chengdu Aupone Pharmaceutical Co.Ltd.
Product
Cenobamate
Price
US $0.00/kg
Min. Order
1kg
Purity
99.99
Supply Ability
10Tons
Release date
2025-01-08

502487-67-4, SQ 109Related Search:


  • SQ 109
  • NSC 722041
  • N-[(2E)-3,7-Dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.1(3,7)]dec-2-yl-1,2-ethanediamine
  • Cenobamate
  • N'-(2-adamantyl)-N-[(2E)-3,7-dimethylocta-2,6-dienyl]ethane-1,2-diamine
  • SQ 109; SQ-109; NSC 722041
  • 1,2-Ethanediamine, N1-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-N2-tricyclo[3.3.1.13,7]dec-2-yl-
  • SQ109 >=98% (HPLC)
  • SQ109 (NSC 722041)
  • N1-((1R,3S,5r,7r)-adamantan-2-yl)-N2-((E)-3,7-dimethylocta-2,6-dien-1-yl)ethane-1,2-diamine
  • SQ109,Parasite,SQ 109,Bacterial,Inhibitor,inhibit,SQ-109,NSC-722041,Antibiotic,NSC722041
  • 1,2-Ethanediamine,N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-
  • SQ109, 10 mM in DMSO
  • 1,2-Ethanediamine,N-[(2E)-3,7-dimethyl-2,6-octadienyl]-N'-tricyclo[3.3.1.13,7]dec-2-yl-
  • 502487-67-4