Trans-4-Hydroxy-L-proline Hydrochloride
- Product Name
- Trans-4-Hydroxy-L-proline Hydrochloride
- CAS No.
- 32968-78-8
- Chemical Name
- Trans-4-Hydroxy-L-proline Hydrochloride
- Synonyms
- L-Hydroxyproline hydrochloride;(4R)-hydroxy-L-proline hydrochloride;Trans-4-Hydroxy-L-proline Hydrochloride;(2S,4R)-trans-4-hydroxy-L-proline hydrochloride;(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride;(2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid Hydrochloride/trans-4-Hydroxy-L-proline hydrochloride
- CBNumber
- CB92629248
- Molecular Formula
- C5H10ClNO3
- Formula Weight
- 167.5908
- MOL File
- 32968-78-8.mol
Trans-4-Hydroxy-L-proline Hydrochloride Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
- optical activity
- Consistent with structure
N-Bromosuccinimide Price
- Product number
- Z5831
- Product name
- Trans-4-hydroxy-L-prolinehydrochloride
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- CM196955
- Product name
- (2S,4R)-4-hydroxypyrrolidine-2-carboxylicacidhydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 32968788
- Product name
- (2S,4R)-4-Hydroxypyrrolidine-2-carboxylicacidhydrochloride
- Packaging
- 5g
- Price
- $192.6
- Updated
- 2021/12/16
- Product number
- 61-11432
- Product name
- (2S,4R)-4-Hydroxypyrrolidine-2-carboxylicacidhydrochloride
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CM196955
- Product name
- (2S,4R)-4-hydroxypyrrolidine-2-carboxylicacidhydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $281
- Updated
- 2021/12/16
Trans-4-Hydroxy-L-proline Hydrochloride Chemical Properties,Usage,Production
Synthesis
364750-80-1
32968-78-8
Step (i)[3] : (2S,4R)-1-(tert-butoxycarbonyl)-4-methylpyrrolidine-2-carboxylic acid (57 g, 262.52 mmol) was dissolved in ethyl ether (150 mL), and an ethyl ether solution of HCl was added slowly (50 mL) with stirring. The reaction mixture was stirred at room temperature overnight. After the reaction was completed, the white solid was collected by filtration and washed with ether (50 mL). The filtrate was cooled to -0 °C and kept for 6 h. The precipitated solid was filtered again and washed with cold water (25 mL). The two batches of solid products were combined and dried under reduced pressure in the presence of phosphorus pentoxide (P2O5) to constant weight to give a white solid (31 g). The structure of the product was confirmed by 1H NMR (D2O): δ 1.94-2.01 (m, 1H), 2.14-2.19 (m, 1H), 3.30-3.48 (m, 2H), 3.71-3.76 (m, 1H), 3.93-4.08 (m, 2H), 4.67-4.75 (m, 1H).
References
[1] Patent: WO2014/25805, 2014, A1. Location in patent: Page/Page column 34
Trans-4-Hydroxy-L-proline Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Trans-4-Hydroxy-L-proline Hydrochloride Suppliers
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View Lastest Price from Trans-4-Hydroxy-L-proline Hydrochloride manufacturers
- Product
- Trans-4-Hydroxy-L-proline Hydrochloride 32968-78-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-14