trans-4-Hydroxy-L-proline methyl ester hydrochloride

Product Name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
CAS No.: 40216-83-9
Chemical Name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
Synonyms: METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE;H-HYP-OME HCL;4-Hydroxy-L-proline methyl ester hydrochloride;trans-4-Hydroxyproline Methyl Ester Hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;Hyp-Ome HCL;H-HYP-OME·HCL;L-Hyp-OMe·HCl;-4-HydroxyproL;H-L-HYP-OME HCL
CBNumber: CB9351552
Molecular Formula: C6H12ClNO3
Formula Weight: 181.62
MOL File: 40216-83-9.mol

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trans-4-Hydroxy-L-proline methyl ester hydrochloride Property

Melting point:: 169 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form: Solid
color: White to Off-White
BRN: 4716932
Stability:: Hygroscopic
InChI: InChI=1/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/s3
InChIKey: KLGSHNXEUZOKHH-SRJSDOSHNA-N
SMILES: [C@@H]1(NC[C@H](O)C1)C(=O)OC.Cl |&1:0,3,r|
CAS DataBase Reference: 40216-83-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 30681
Product name: L-4-Hydroxyproline methyl ester hydrochloride
Purity: ≥98.0% (TLC)
Packaging: 5g
Price: $60.4
Updated: 2025/07/31

TCI Chemical

Product number: H1533
Product name: trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride
Packaging: 5G
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: H1533
Product name: trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride
Packaging: 25G
Price: $126
Updated: 2025/07/31

Usbiological

Product number: 279443
Product name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
Packaging: 50g
Price: $337
Updated: 2021/12/16

TRC

Product number: H952395
Product name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
Packaging: 50g
Price: $340
Updated: 2021/12/16

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trans-4-Hydroxy-L-proline methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

32968-78-8

40216-83-9

The general procedure for synthesizing trans-4-hydroxy-L-proline methyl ester hydrochloride from methanol and trans-4-hydroxy-L-proline hydrochloride is as follows: Example 1: (2S,4R)-4-hydroxy-2-pyrrolidine carboxylic acid hydrochloride (1.0 g, 7.6 mmol) was dissolved in methanol (25 mL) and cooled to 0°C. Thionyl chloride (0.83 mL, 11.4 mmol) was added slowly under stirring. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure to afford trans-4-hydroxy-L-proline methyl ester hydrochloride (1.2 g, 92% yield) in white solid form. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6).

IC 50

Non-cleavable Linker

References

[1] Organic Letters, 2018, vol. 20, # 1, p. 162 - 165
[2] Patent: WO2013/174937, 2013, A1. Location in patent: Page/Page column 74
[3] Patent: US2015/152048, 2015, A1. Location in patent: Paragraph 0447-0448

trans-4-Hydroxy-L-proline methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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trans-4-Hydroxy-L-proline methyl ester hydrochloride Suppliers

Belgium 2 Canada 2 China 322 Europe 3 Germany 7 India 14 Israel 1 Japan 6 South Korea 1 Switzerland 2 United Kingdom 13 United States 46 Global 419

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View Lastest Price from trans-4-Hydroxy-L-proline methyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98.0%min
Supply Ability: 500kgs
Release date: 2021-08-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Hyp-Ome·HCl 40216-83-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-24

Nanjing Fred Technology Co., Ltd

Product: trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

40216-83-9, trans-4-Hydroxy-L-proline methyl ester hydrochlorideRelated Search:

Topotecan hydrochloride Kresoxim-methyl 4-Hydroxyaniline hydrochloride cis-4-Hydroxy-L-proline CHLOROPHOSPHONAZO III Methyl glycolate Methylparaben L-Hydroxyproline D-Proline L-PROLINE-(4-3H(N)) Methyl L-prolinate hydrochloride Methyl acrylate Bensulfuron methyl H-HYP(BZL)-OH HCL H-HYP(TBU)-OH Trans-4-Hydroxy-L-proline Hydrochloride Thiophanate-methyl trans-4-Hydroxy-D-proline

H-HYP-OME HCL

H-L-HYP-OME HCL

HYDROXYPROLINE-OME HCL

(2S,4R)-trans-4-hydroxy-L-proline methyl ester hydrochloride

4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester hydrochloride

L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT

L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT

L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT

L-HYDROXYPROLINE METHYL ESTER HCL

L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE

(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE

TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE

TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE SALT

TRANS-L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

TIMTEC-BB SBB003740

H-HYP-OME·HCL

4-HYDROXY-L-PROLINE METHYL ESTER HCl

(2s,4r)-Methyl 4-Hydroxy-Pyrrolidine-2-Carboxylate HCl

Hyp-Ome HCL

(2S,4R)-4-hydroxy-L-proline methyl ester

L-4-HYDROXYPROLINE METHYL ESTER HYDROCHL

(2R,4S)-4-hydroxy-D-proline methyl ester

Methyl (2S,4R)-4-hydroxy-2-prolinate hydrochloride

4-Hydroxy-L-proline methyl ester hydrochloride

TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HCL

L-Hyp-OMe·HCl

L-4-trans-Hydroxyproline methyl ester hydrochloride≥ 97% (HPLC)

H-Hyp-OMe·HCl (Non-animal Origin)

Hydroxyproline methyl ester hydrochloride

(4R)-4-Hydroxy-L-proline methyl ester HCl

(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

L-4-Hydroxyproline methyl ester hydrochloride ,98%

Methyl (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylate Hydrochloride

Methyl L-Hydroxyprolinate Hydrochloride

Methyl trans-4-Hydroxy-L-prolinate Hydrochloride

trans-4-Hydroxyproline Methyl Ester Hydrochloride

<i>trans</i>-4-Hydroxy-L-proline Methyl ester hydrochloride

trans-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

4-hydroxy-pyrrolidine-2-carboxylic acid Methyl ester hydrochloride

Trans-4-hydroxyl-lprolinemethylesterhydrochloride

Methyl (2S)-1-hydroxypyrrolidine-2-carboxylate hydrochloride

L-(S)-4-Hydroxyproline Methyl Ester Hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride, Methyl (4R)-4-hydroxy-L-prolinate hydrochloride

L-4-Hydroxyproline Methyl ester hydrochloride >=98.0% (TLC)

L-4-Hydroxyproline Methyl ester hydrochloride, 95+%

L-4-Hydroxyproline methyl ester

trans-4-Hydroxy-L-prolineMethylEsterHydrochloride&gt

-4-HydroxyproL

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride USP/EP/BP

H-Hyp-OMe (hydrochloride)

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester HCl

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/trans-4-HYDROXY-L-PROLINE METHYL ESTER Hydrochloride

<sc>L</sc>-4-Hydroxyproline methyl ester hydrochloride

40216-83-9