ChemicalBook > CAS DataBase List > trans-4-Hydroxy-L-proline methyl ester hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride

Product Name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
CAS No.: 40216-83-9
Chemical Name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
Synonyms: METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE;H-HYP-OME HCL;4-Hydroxy-L-proline methyl ester hydrochloride;trans-4-Hydroxyproline Methyl Ester Hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;Hyp-Ome HCL;H-HYP-OME·HCL;L-Hyp-OMe·HCl;-4-HydroxyproL;H-L-HYP-OME HCL
CBNumber: CB9351552
Molecular Formula: C6H12ClNO3
Formula Weight: 181.62
MOL File: 40216-83-9.mol

Less

trans-4-Hydroxy-L-proline methyl ester hydrochloride Property

Melting point:: 169 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form: Solid
color: White to Off-White
BRN: 4716932
Stability:: Hygroscopic
InChI: InChI=1/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/s3
InChIKey: KLGSHNXEUZOKHH-SRJSDOSHNA-N
SMILES: [C@@H]1(NC[C@H](O)C1)C(=O)OC.Cl |&1:0,3,r|
CAS DataBase Reference: 40216-83-9(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
HS Code: 29339900

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 30681
Product name: L-4-Hydroxyproline methyl ester hydrochloride
Purity: ≥98.0% (TLC)
Packaging: 5g
Price: $60.4
Updated: 2025/07/31

TCI Chemical

Product number: H1533
Product name: trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride
Packaging: 5G
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: H1533
Product name: trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride
Packaging: 25G
Price: $126
Updated: 2025/07/31

Usbiological

Product number: 279443
Product name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
Packaging: 50g
Price: $337
Updated: 2021/12/16

TRC

Product number: H952395
Product name: trans-4-Hydroxy-L-proline methyl ester hydrochloride
Packaging: 50g
Price: $340
Updated: 2021/12/16

Less

trans-4-Hydroxy-L-proline methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

32968-78-8

40216-83-9

The general procedure for synthesizing trans-4-hydroxy-L-proline methyl ester hydrochloride from methanol and trans-4-hydroxy-L-proline hydrochloride is as follows: Example 1: (2S,4R)-4-hydroxy-2-pyrrolidine carboxylic acid hydrochloride (1.0 g, 7.6 mmol) was dissolved in methanol (25 mL) and cooled to 0°C. Thionyl chloride (0.83 mL, 11.4 mmol) was added slowly under stirring. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure to afford trans-4-hydroxy-L-proline methyl ester hydrochloride (1.2 g, 92% yield) in white solid form. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6).

IC 50

Non-cleavable Linker

References

[1] Organic Letters, 2018, vol. 20, # 1, p. 162 - 165
[2] Patent: WO2013/174937, 2013, A1. Location in patent: Page/Page column 74
[3] Patent: US2015/152048, 2015, A1. Location in patent: Paragraph 0447-0448

trans-4-Hydroxy-L-proline methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

trans-4-Hydroxy-L-proline methyl ester hydrochloride Suppliers

Belgium 2 Canada 2 China 322 Europe 3 Germany 7 India 14 Israel 1 Japan 6 South Korea 1 Switzerland 2 United Kingdom 13 United States 46 Global 419

YangZhou Ruihong Biotech Co., Ltd.

Tel: 0514-015380367604 15380367604
Fax: 0514-83828236
Email: sales@ruibobiotech.com
Country: China
ProdList: 511
Advantage: 55

Nantong puyue biomedical Co., Ltd

Tel: 0513-0513-0513-89158300 18014392889
Fax: 0513-89158198
Email: sales@puyerbiopharma.com
Country: China
ProdList: 4956
Advantage: 58

Yangzhou Xuda Biotechnology Co., Ltd

Tel: 15161820588; 15161820588
Email: xdchemical2024@163.com
Country: China
ProdList: 91
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Shanghai Chiral Chemicals Inc.

Tel: 021-37285021 13472570865
Fax: 86-021-51714507
Email: tym7xi@aliyun.com
Country: China
ProdList: 308
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

AF Biochem Co., Ltd.

Tel: +86-028-60911900 13540204019
Email: sales@afbiochem.com
Country: China
ProdList: 479
Advantage: 57

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Chengdu Pukang Biotechnology Co., Ltd

Tel: +86-028-82550498 +86-19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 497
Advantage: 58

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 4131
Advantage: 55

Accendatech Co., LTD.

Tel: 13132578992
Fax: 022-83718543-802
Email: sales@accendatech.com
Country: China
ProdList: 332
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: +86-21-60341587
Fax: +86-21-61294319
Email: sales@topbiochem.com
Country: China
ProdList: 6175
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD.

Tel: 21-33585366 13311639313
Fax: +86-21-34979012
Email: sales@shyrchem.com
Country: China
ProdList: 806
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
Fax: 025-84699383-8003
Email: njduly@126.com
Country: China
ProdList: 3249
Advantage: 55

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

Tianjin Chempharmatech Co.,Ltd.

Tel: 022-66211079 13212288319
Fax: qq1405432731
Email: sales@chempharmatech.com
Country: China
ProdList: 918
Advantage: 55

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Beijing Universal Century Technology Co., Ltd.

Tel: 400-8706899
Fax: 400-8706899
Email: hysj_bj.com
Country: China
ProdList: 3583
Advantage: 55

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Less

View Lastest Price from trans-4-Hydroxy-L-proline methyl ester hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9
Price: US $0.00/Kg/Bag
Min. Order: 100g
Purity: 98.0%min
Supply Ability: 500kgs
Release date: 2021-08-23

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-L-Hyp-Ome·HCl 40216-83-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-24

Nanjing Fred Technology Co., Ltd

Product: trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

40216-83-9, trans-4-Hydroxy-L-proline methyl ester hydrochlorideRelated Search:

Topotecan hydrochloride Kresoxim-methyl 4-Hydroxyaniline hydrochloride cis-4-Hydroxy-L-proline CHLOROPHOSPHONAZO III Methyl glycolate Methylparaben L-Hydroxyproline D-Proline L-PROLINE-(4-3H(N)) Methyl L-prolinate hydrochloride Methyl acrylate Bensulfuron methyl H-HYP(BZL)-OH HCL H-HYP(TBU)-OH Trans-4-Hydroxy-L-proline Hydrochloride Thiophanate-methyl trans-4-Hydroxy-D-proline

H-HYP-OME HCL

H-L-HYP-OME HCL

HYDROXYPROLINE-OME HCL

(2S,4R)-trans-4-hydroxy-L-proline methyl ester hydrochloride

4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester hydrochloride

L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT

L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT

L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT

L-HYDROXYPROLINE METHYL ESTER HCL

L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE

(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE

TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE

TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE SALT

TRANS-L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE

TIMTEC-BB SBB003740

H-HYP-OME·HCL

4-HYDROXY-L-PROLINE METHYL ESTER HCl

(2s,4r)-Methyl 4-Hydroxy-Pyrrolidine-2-Carboxylate HCl

Hyp-Ome HCL

(2S,4R)-4-hydroxy-L-proline methyl ester

L-4-HYDROXYPROLINE METHYL ESTER HYDROCHL

(2R,4S)-4-hydroxy-D-proline methyl ester

Methyl (2S,4R)-4-hydroxy-2-prolinate hydrochloride

4-Hydroxy-L-proline methyl ester hydrochloride

TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HCL

L-Hyp-OMe·HCl

L-4-trans-Hydroxyproline methyl ester hydrochloride≥ 97% (HPLC)

H-Hyp-OMe·HCl (Non-animal Origin)

Hydroxyproline methyl ester hydrochloride

(4R)-4-Hydroxy-L-proline methyl ester HCl

(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

L-4-Hydroxyproline methyl ester hydrochloride ,98%

Methyl (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylate Hydrochloride

Methyl L-Hydroxyprolinate Hydrochloride

Methyl trans-4-Hydroxy-L-prolinate Hydrochloride

trans-4-Hydroxyproline Methyl Ester Hydrochloride

<i>trans</i>-4-Hydroxy-L-proline Methyl ester hydrochloride

trans-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride

4-hydroxy-pyrrolidine-2-carboxylic acid Methyl ester hydrochloride

Trans-4-hydroxyl-lprolinemethylesterhydrochloride

Methyl (2S)-1-hydroxypyrrolidine-2-carboxylate hydrochloride

L-(S)-4-Hydroxyproline Methyl Ester Hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride, Methyl (4R)-4-hydroxy-L-prolinate hydrochloride

L-4-Hydroxyproline Methyl ester hydrochloride >=98.0% (TLC)

L-4-Hydroxyproline Methyl ester hydrochloride, 95+%

L-4-Hydroxyproline methyl ester

trans-4-Hydroxy-L-prolineMethylEsterHydrochloride&gt

-4-HydroxyproL

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride USP/EP/BP

H-Hyp-OMe (hydrochloride)

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester HCl

(2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/trans-4-HYDROXY-L-PROLINE METHYL ESTER Hydrochloride

<sc>L</sc>-4-Hydroxyproline methyl ester hydrochloride

40216-83-9