Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- Product Name
- Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- CAS No.
- 178606-66-1
- Chemical Name
- Carbonic Anhydrase IX/XII Inhibitor II(U-104)
- Synonyms
- U-104;DNAJA4;CS-1653;MSTP104;PRO1472;MST-104 ;SLC-0111;NSC 213841;U-104, >98%;U104(SLC-0111)
- CBNumber
- CB92630071
- Molecular Formula
- C13H12FN3O3S
- Formula Weight
- 309.32
- MOL File
- 178606-66-1.mol
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Property
- Melting point:
- 242-243℃
- Density
- 1.523±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- 2-8°C
- solubility
- DMSO: >15mg/mL
- form
- powder
- pka
- 9.94±0.12(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0374
- Product name
- U-104
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- SML0374
- Product name
- U-104
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $458
- Updated
- 2024/03/01
- Product number
- HPA041790
- Product name
- Anti-DNAJA4 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
- Packaging
- 100μL
- Price
- $580
- Updated
- 2024/03/01
- Product number
- 215901
- Product name
- Carbonic Anhydrase IX/XII Inhibitor II, U-104
- Purity
- The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.
- Packaging
- 5MG
- Price
- $130
- Updated
- 2024/03/01
- Product number
- HPA041790
- Product name
- Anti-DNAJA4 antibody produced in rabbit
- Purity
- Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
- Packaging
- 25μL
- Price
- $282
- Updated
- 2023/06/20
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Chemical Properties,Usage,Production
Uses
U 104 targets hypoxia-induced carbonic anhydrase IX, which inhibits tumor growth and metastasis.
Biological Activity
u-104 is a novel ureido-sulfonamide inhibitor of carbonic anhydrase ix (caix). tumor volume measurements show important inhibition of primary tumor growth in the mice treated with the u-104 compound compared with vehicle controls. it also has ability to inhibit metastasis formation in the 4t1 experimental metastasis model.yuanmei lou, paul c. mcdonald, arusha oloumi, stephen chia, christina ostlund, ardalan ahmadi, alastair kyle, ulrich auf dem keller, samuel leung, david huntsman, blaise clarke, brent w. sutherland, dawn waterhouse, marcel bally, calvin roskelley, christopher m. overall, andrew minchinton, fabio pacchiano, fabrizio carta, andrea scozzafava, nadia touisni, jean-yves winum, claudiu t. supuran, shoukat dedhar. targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase ix inhibitors. cancer research may 1, 2011 71; 3364
Biochem/physiol Actions
U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
Carbonic Anhydrase IX/XII Inhibitor II(U-104) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbonic Anhydrase IX/XII Inhibitor II(U-104) manufacturers
- Product
- U-104 178606-66-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2019-12-31
- Product
- Carbonic Anhydrase IX/XII Inhibitor II(U-104) 178606-66-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05