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tiraseMtiv (CK-2017357)

Product Name
tiraseMtiv (CK-2017357)
CAS No.
1005491-05-3
Chemical Name
tiraseMtiv (CK-2017357)
Synonyms
CS-1484;TiraseMtiv;CK 2017357;Tirasemitiv;Tirasemtiv, >=98%;tiraseMtiv (CK-2017357);Tirasemtiv(CK-2017357), >98%;CK-2017357; CK2017357; CK 2017357;inhibit,Tirasemtiv,Inhibitor,CK2017357,CK 2017357;5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one
CBNumber
CB92631164
Molecular Formula
C12H14N4O
Formula Weight
230.27
MOL File
1005491-05-3.mol
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tiraseMtiv (CK-2017357) Property

Melting point:
>130°C (dec.)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Beige to Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
5mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
10mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
25mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
50mg
Price
$272
Updated
2024/03/01
TRC
Product number
T446700
Product name
Tirasemtiv
Packaging
25mg
Price
$150
Updated
2021/12/16
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tiraseMtiv (CK-2017357) Chemical Properties,Usage,Production

Description

Tirasemtiv is an activator of the fast skeletal troponin complex. It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.

Uses

Tirasemtiv is a fast skeletal muscle troponin activator and is used for treating patients with amyotrophic lateral sclerosis (ALS).

tiraseMtiv (CK-2017357) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from tiraseMtiv (CK-2017357) manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
Tirasemtiv;CK-2017357 1005491-05-3
Price
US $500.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-24
Career Henan Chemical Co
Product
tiraseMtiv (CK-2017357) 1005491-05-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
200KG
Release date
2018-08-19

1005491-05-3, tiraseMtiv (CK-2017357)Related Search:


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