ChemicalBook > CAS DataBase List > tiraseMtiv (CK-2017357)

tiraseMtiv (CK-2017357)

Product Name
tiraseMtiv (CK-2017357)
CAS No.
1005491-05-3
Chemical Name
tiraseMtiv (CK-2017357)
Synonyms
CS-1484;TiraseMtiv;CK 2017357;Tirasemitiv;Tirasemtiv, >=98%;tiraseMtiv (CK-2017357);Tirasemtiv, 10 mM in DMSO;Tirasemtiv(CK-2017357), >98%;Troponin Activator, CK-2017357;CK-2017357; CK2017357; CK 2017357
CBNumber
CB92631164
Molecular Formula
C12H14N4O
Formula Weight
230.27
MOL File
1005491-05-3.mol
More
Less

tiraseMtiv (CK-2017357) Property

Melting point:
>130°C (dec.)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
Beige to Brown
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
5mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
10mg
Price
$84
Updated
2024/03/01
Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
25mg
Price
$182
Updated
2024/03/01
Cayman Chemical
Product number
26075
Product name
Tirasemtiv
Purity
≥98%
Packaging
50mg
Price
$272
Updated
2024/03/01
TRC
Product number
T446700
Product name
Tirasemtiv
Packaging
25mg
Price
$150
Updated
2021/12/16
More
Less

tiraseMtiv (CK-2017357) Chemical Properties,Usage,Production

Description

Tirasemtiv is an activator of the fast skeletal troponin complex. It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.

Uses

Tirasemtiv is a fast skeletal muscle troponin activator and is used for treating patients with amyotrophic lateral sclerosis (ALS).

in vivo

A single dose of Tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in Tirasemtiv-treated female B6SJL-SOD1G93A mice. At the 25% deficit milestone, vehicle-treated B6SJL-SOD1G93A mice demonstrated forelimb grip strength of 49.6±4.6 g. Tirasemtiv increases grip strength by 38% to 68.6±8.1g (p<0.05, single tailed t-test). Tirasemtiv doses of 2, 2, 2, and 4 mg/kg given at approximately 20 min intervals to achieve a cumulative dose of 10 mg/kg. Regression analysis of the log dose vs. response relationship indicated that Tirasemtiv significantly increased muscle force in WT and mid-stage B6SJL-SOD1G93A mice (WT p<0.0001; mid-stage p=0.0028). At later stages of disease, the mice exhibited a trend for increased muscle function in response to Tirasemtivcompared to baseline (p=0.064)[1].

References

[1] ALAN J RUSSELL. Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases[J]. Nature Medicine, 2012, 18 3: 452-455. DOI: 10.1038/nm.2618
[2] DARREN T HWEE. Fast skeletal muscle troponin activator tirasemtiv increases muscle function and performance in the B6SJL-SOD1G93A ALS mouse model.[J]. PLoS ONE, 2014: e96921. DOI: 10.1371/journal.pone.0096921

tiraseMtiv (CK-2017357) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tiraseMtiv (CK-2017357) Suppliers

China 85 India 3 United States 11 Global 99
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
More
Less

View Lastest Price from tiraseMtiv (CK-2017357) manufacturers

Wuhan Nutra Biotechnology Co.,Ltd
Product
Tirasemtiv;CK-2017357 1005491-05-3
Price
US $500.00-0.00/g
Min. Order
1g
Purity
98%+
Supply Ability
100kgs
Release date
2021-05-24
Career Henan Chemical Co
Product
tiraseMtiv (CK-2017357) 1005491-05-3
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
200KG
Release date
2018-08-19

1005491-05-3, tiraseMtiv (CK-2017357)Related Search:


  • tiraseMtiv (CK-2017357)
  • 6-ethynyl-1-(pentan-3-yl)-1H-iMidazo[4,5-b]pyrazin-2-ol
  • TiraseMtiv
  • 6-ETHYNYL-1-(PENTAN-3-YL)-1H-IMIDAZO[4,5-B]PYRAZIN-2(3H)-ONE
  • 1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
  • CK 2017357
  • Tirasemtiv 1-(1-Ethylpropyl)-6-ethynyl-1,3-dihydro-2H-imidazo[4,5-b]pyrazin-2-one
  • Tirasemtiv, >=98%
  • CK-2017357; CK2017357; CK 2017357
  • CS-1484
  • Tirasemitiv
  • Tirasemtiv(CK-2017357), >98%
  • 5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one
  • 2H-Imidazo[4,5-b]pyrazin-2-one, 1-(1-ethylpropyl)-6-ethynyl-1,3-dihydro-
  • inhibit,Tirasemtiv,Inhibitor,CK2017357,CK 2017357
  • Tirasemtiv, 10 mM in DMSO
  • Troponin Activator, CK-2017357
  • 6-ethynyl-1-(pentan-3-yl)-1,3-dihydro-2h-imidazo[4,5-b]pyrazin-2-one
  • 1005491-05-3