tiraseMtiv (CK-2017357)
- Product Name
- tiraseMtiv (CK-2017357)
- CAS No.
- 1005491-05-3
- Chemical Name
- tiraseMtiv (CK-2017357)
- Synonyms
- CS-1484;TiraseMtiv;CK 2017357;Tirasemitiv;Tirasemtiv, >=98%;tiraseMtiv (CK-2017357);Tirasemtiv(CK-2017357), >98%;CK-2017357; CK2017357; CK 2017357;inhibit,Tirasemtiv,Inhibitor,CK2017357,CK 2017357;5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one
- CBNumber
- CB92631164
- Molecular Formula
- C12H14N4O
- Formula Weight
- 230.27
- MOL File
- 1005491-05-3.mol
tiraseMtiv (CK-2017357) Property
- Melting point:
- >130°C (dec.)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Beige to Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 26075
- Product name
- Tirasemtiv
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 26075
- Product name
- Tirasemtiv
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $84
- Updated
- 2024/03/01
- Product number
- 26075
- Product name
- Tirasemtiv
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $182
- Updated
- 2024/03/01
- Product number
- 26075
- Product name
- Tirasemtiv
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $272
- Updated
- 2024/03/01
- Product number
- T446700
- Product name
- Tirasemtiv
- Packaging
- 25mg
- Price
- $150
- Updated
- 2021/12/16
tiraseMtiv (CK-2017357) Chemical Properties,Usage,Production
Description
Tirasemtiv is an activator of the fast skeletal troponin complex. It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.
Uses
Tirasemtiv is a fast skeletal muscle troponin activator and is used for treating patients with amyotrophic lateral sclerosis (ALS).
tiraseMtiv (CK-2017357) Preparation Products And Raw materials
Raw materials
Preparation Products
tiraseMtiv (CK-2017357) Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
View Lastest Price from tiraseMtiv (CK-2017357) manufacturers
- Product
- Tirasemtiv;CK-2017357 1005491-05-3
- Price
- US $500.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%+
- Supply Ability
- 100kgs
- Release date
- 2021-05-24
- Product
- tiraseMtiv (CK-2017357) 1005491-05-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 200KG
- Release date
- 2018-08-19