ChemicalBook > CAS DataBase List > 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride

4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride

Product Name
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
CAS No.
193356-17-1
Chemical Name
4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
Synonyms
184833;Co 101244 HCl;1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-;Co 101244 hydrochloride (also known as PD 174494 and Ro 63-1908);1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol hydrochloride;4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride;Inhibitor,Co 101244,Co-101244,Co 101244 hydrochloride,Ionotropic glutamate receptors,inhibit,NR2B,Co101244,PD174494,iGluR,PD 174494,neuroprotective,PD-174494,NMDA
CBNumber
CB92639337
Molecular Formula
C21H28ClNO3
Formula Weight
377.90492
MOL File
193356-17-1.mol
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4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Property

Melting point:
133-135 °C
storage temp. 
Store at -20°C
solubility 
Soluble to 100 mM in water and to 50 mM in DMSO
form 
Powder
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C781033
Product name
Co101244Hydrochloride
Packaging
1mg
Price
$100
Updated
2021/12/16
TRC
Product number
C781033
Product name
Co101244Hydrochloride
Packaging
2.5mg
Price
$220
Updated
2021/12/16
ApexBio Technology
Product number
B7062
Product name
Co101244hydrochloride
Packaging
10mg
Price
$294
Updated
2021/12/16
ApexBio Technology
Product number
B7062
Product name
Co101244hydrochloride
Packaging
50mg
Price
$1246
Updated
2021/12/16
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4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Chemical Properties,Usage,Production

Description

Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC50values are 0.043, > 100 and > 100μM for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effectsin vivoandin vitro.

Uses

Co 101244 (PD 174494) hydrochloride is a NR2B-containing NMDA receptor antagonist[1].

in vivo

Co 101244 (0.1, 1 mg/kg s.c.) displayed antidyskinetic effects (67 and 71% reduction, respectively) while sparing levodopa motor benefit[1].

storage

Store at +4°C

References

[1] Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9. DOI:10.1073/pnas.0903546106

4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride Suppliers

China 25 United Kingdom 1 United States 3 Global 29
ChemShuttle, Inc.
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193356-17-1, 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochlorideRelated Search:


  • 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-,hydrochloride
  • 1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol hydrochloride
  • 184833
  • Co 101244 hydrochloride (also known as PD 174494 and Ro 63-1908)
  • 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-
  • Inhibitor,Co 101244,Co-101244,Co 101244 hydrochloride,Ionotropic glutamate receptors,inhibit,NR2B,Co101244,PD174494,iGluR,PD 174494,neuroprotective,PD-174494,NMDA
  • Co 101244 HCl
  • 193356-17-1