6-broMo-4-chloro-7-Methoxy-quinoline

Application

Product Name: 6-broMo-4-chloro-7-Methoxy-quinoline
CAS No.: 476660-71-6
Chemical Name: 6-broMo-4-chloro-7-Methoxy-quinoline
Synonyms: 6-broMo-4-chloro-7-Methoxy-quinoline;Quinoline, 6-bromo-4-chloro-7-methoxy-
CBNumber: CB92651014
Molecular Formula: C10H7BrClNO
Formula Weight: 272.53
MOL File: 476660-71-6.mol

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6-broMo-4-chloro-7-Methoxy-quinoline Property

Boiling point:: 348.9±37.0 °C(Predicted)
Density: 1.613±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.10±0.30(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C10H7BrClNO/c1-14-10-5-9-6(4-7(10)11)8(12)2-3-13-9/h2-5H,1H3
InChIKey: UZQYUZCQWPAWIL-UHFFFAOYSA-N
SMILES: N1C2C(=CC(Br)=C(OC)C=2)C(Cl)=CC=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0041246
Product name: 6-Bromo-4-chloro-7-methoxyquinoline
Purity: 97.83%
Packaging: 250mg
Price: $63
Updated: 2021/12/16

ChemScene

Product number: CS-0041246
Product name: 6-Bromo-4-chloro-7-methoxyquinoline
Purity: 97.83%
Packaging: 1g
Price: $157
Updated: 2021/12/16

AK Scientific

Product number: 5990DA
Product name: 6-Bromo-4-chloro-7-methoxyquinoline
Packaging: 100mg
Price: $376
Updated: 2021/12/16

ChemScene

Product number: CS-0041246
Product name: 6-Bromo-4-chloro-7-methoxyquinoline
Purity: 97.83%
Packaging: 5g
Price: $497
Updated: 2021/12/16

ChemScene

Product number: CS-0041246
Product name: 6-Bromo-4-chloro-7-methoxyquinoline
Purity: 97.83%
Packaging: 10g
Price: $984
Updated: 2021/12/16

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6-broMo-4-chloro-7-Methoxy-quinoline Chemical Properties,Usage,Production

Application

6-Bromo-4-chloro-7-methoxyquinoline can be used as a pharmaceutical synthesis intermediate.

Synthesis

1361235-54-2

476660-71-6

General procedure for the synthesis of 6-bromo-4-chloro-7-methoxyquinolin-4-ol from 6-bromo-7-methoxyquinolin-4-ol: 6-bromo-7-methoxyquinolin-4-ol (4.17 g, 16.4 mmol) was dissolved in phosphorus trichloride (8 mL, 82 mmol) and the reaction was stirred for 1 h at 110 °C. The reaction was carried out in aqueous solution of saturated sodium carbonate. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice-cooled saturated aqueous sodium carbonate solution with stirring. The solid product in the resulting suspension was collected by filtration, washed well with water and subsequently dried under vacuum overnight to afford the target compound 6-bromo-4-chloro-7-methoxyquinoline (4.6 g, 16 mmol, 97% yield).LCMS assay: retention time (RT) = 1.18 min, mass spectrum (ESI+) m/z: 272, 274 [M+H] +.

References

[1] Patent: WO2016/169989, 2016, A1. Location in patent: Page/Page column 54; 55
[2] Patent: WO2017/46036, 2017, A1. Location in patent: Page/Page column 50
[3] Patent: TWI609011, 2017, B. Location in patent: Page/Page column 66; 67
[4] Patent: EP2680844, 2016, B1. Location in patent: Paragraph 0123
[5] Patent: TW2018/8946, 2018, A. Location in patent: Page/Page column 56; 57

6-broMo-4-chloro-7-Methoxy-quinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6-broMo-4-chloro-7-Methoxy-quinoline Suppliers

China 55 India 1 United States 3 Global 59

Porse Fine Chemical Co.,LTD

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View Lastest Price from 6-broMo-4-chloro-7-Methoxy-quinoline manufacturers

Career Henan Chemical Co

Product: 6-broMo-4-chloro-7-Methoxy-quinoline 476660-71-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: ask
Release date: 2019-12-19

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