6-BroMo-n,n-diMethylpyridine-3-aMine
- Product Name
- 6-BroMo-n,n-diMethylpyridine-3-aMine
- CAS No.
- 39856-56-9
- Chemical Name
- 6-BroMo-n,n-diMethylpyridine-3-aMine
- Synonyms
- 6-broMo-N,N-diMethylpyridin-3-aMine;6-BroMo-n,n-diMethylpyridine-3-aMine;(6-BroMo-pyridin-3-yl)-diMethyl-aMine;3-PyridinaMine, 6-broMo-N,N-diMethyl-;6-bromo-N,N-dimethylpyridin-3-amine,2-bromo-5-dimethylaminopyridine
- CBNumber
- CB92651726
- Molecular Formula
- C7H9BrN2
- Formula Weight
- 201.06
- MOL File
- 39856-56-9.mol
6-BroMo-n,n-diMethylpyridine-3-aMine Property
- Melting point:
- 64-66 °C(Solv: hexane (110-54-3))
- Boiling point:
- 278.8±20.0 °C(Predicted)
- Density
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.96±0.22(Predicted)
- Appearance
- Off-white to yellow Solid
N-Bromosuccinimide Price
- Product number
- B593625
- Product name
- 6-bromo-N,N-dimethylpyridin-3-amine
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- FB142462
- Product name
- 6-Bromo-N,N-dimethylpyridin-3-amine
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB142462
- Product name
- 6-Bromo-N,N-dimethylpyridin-3-amine
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FB142462
- Product name
- 6-Bromo-N,N-dimethylpyridin-3-amine
- Packaging
- 2g
- Price
- $171
- Updated
- 2021/12/16
- Product number
- 189332
- Product name
- 6-Bromo-N,N-dimethylpyridin-3-amine
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
6-BroMo-n,n-diMethylpyridine-3-aMine Chemical Properties,Usage,Production
Synthesis
13534-97-9
74-88-4
39856-56-9
5-Amino-2-bromopyridine (300 mg, 1.73 mmol) was dissolved in tetrahydrofuran (30 mL) under nitrogen protection and cooled to -78 °C. A tetrahydrofuran solution of 1 M bis(trimethylmethylsilyl)lithium amide (3.46 mL, 3.46 mmol) was slowly added to this solution over 6 min. After maintaining -78 °C and stirring for 30 min, iodomethane (566 mg, 3.99 mmol) was added. The reaction mixture was gradually warmed to room temperature and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (50 mL). The reaction mixture was extracted with ethyl acetate (3 x 50 mL) and the organic phases were combined. The organic phase was washed sequentially with brine (2 x 50 mL) and dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the resulting residue was purified by silica gel column chromatography with the eluent being a petroleum ether solution of 1-10% ethyl acetate to give 6-bromo-N,N-dimethylpyridin-3-amine as a light yellow solid. Mass spectrum (ESI, m/z): 201.0,203.0 [M + 1]+.
References
[1] Patent: WO2015/188368, 2015, A1. Location in patent: Page/Page column 54
6-BroMo-n,n-diMethylpyridine-3-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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