TD-198946
- Product Name
- TD-198946
- CAS No.
- 364762-86-7
- Chemical Name
- TD-198946
- Synonyms
- TD-198946;TD-198946, >98%;TD198946;TD 198946;TD-198946, 10 mM in DMSO;TD-198946,inhibit,Inhibitor;1-(3-PYRIDINYLMETHYL)-4-PIPERIDINOL DIHYDROCHLORIDE;1H-THIENO[3,4-G]INDAZOLE-6-CARBOXAMIDE, 4,5-DIHYDRO-1-METHYL-8-[4-(2-QUIN+;1-methyl-8-{4-[(quinolin-2-yl)methoxy]phenoxy}-1H,4H,5H-thieno[3,4-g]indazole-6-carboxamide;4,5-dihydro-1-methyl-8-[4-(2-quinolinylmethoxy)phenoxy]-1H-thieno[3,4-g]indazole-6-carboxamide;1-Methyl-8-(4-(quinolin-2-ylmethoxy)phenoxy)-4,5-dihydro-1H-thieno[3,4-g]indazole-6-carboxamide
- CBNumber
- CB92655421
- Molecular Formula
- C27H22N4O3S
- Formula Weight
- 482.55
- MOL File
- 364762-86-7.mol
TD-198946 Property
- Boiling point:
- 699.5±55.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 15.87±0.20(Predicted)
- form
- Solid
- color
- White to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CSN27600
- Product name
- TD-198946
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- A708965
- Product name
- Td-198946
- Purity
- 98%
- Packaging
- 5mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- CSN27600
- Product name
- TD-198946
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- CSN27600
- Product name
- TD-198946
- Packaging
- 10g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- DC10118
- Product name
- TD-198946
- Purity
- >98%
- Packaging
- 100mg
- Price
- $800
- Updated
- 2021/12/16
TD-198946 Chemical Properties,Usage,Production
Uses
TD-198946, a thienoindazole derivative, is a potent chondrogenic agent.
Biological Activity
TD-198946 is a thienoazole derivative,it is a highly potent cartilage-forming agent.
in vitro
TD-198946 is a potent chondrogenic agent. TD-198946 strongly induces chondrogenic differentiation without promoting hypertrophy in cell and metatarsal organ cultures. TD-198946 induces stronger Col2a1 promoter activity than insulin in ATDC5 cells. In C3H10T1/2 cells, ATDC5 cells and primary mouse chondrocytes, TD-198946 dose-dependently stimulates endogenous expression of the chondrocyte markers Col2a1 and Acan , with maximum effects around 1-10 μM.
in vivo
When administered directly into the joint space, TD-198946 successfully prevents and repaires degeneration of the articular cartilage.It exerts its effect through the regulation of Runx1 expression, which is downregulated in both mouse and human OA cartilage compared with normal tissue.It has disease-modifying effects on progressed osteoarthritis.It may prevent the progression of osteoarthritis by acting on the remaining chondrocytes rather than repairing damaged cartilage, it may be most effective as a therapeutic during the early or middle stages of osteoarthritis, before the articular cartilage is fully eroded. Cartilaginous cell-sheets are generated by culturing mouse and canine costal chondrocytes and human mesenchymal stem cells with TD-198946 on temperature-responsive dishes.
References
[1] Yano F, et al. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis. 2013 May;72(5):748-53. DOI:10.1136/annrheumdis-2012-201745
[2] Yano F, et al. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73(11):2062-4. DOI:10.1136/annrheumdis-2014-205672
[3] Yano F, et al. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials. 2013 Jul;34(22):5581-7. DOI:10.1016/j.biomaterials.2013.04.008
[4] Kobayashi M, Chijimatsu R, Hart DA, et al. Evidence that TD-198946 enhances the chondrogenic potential of human synovium-derived stem cells through the NOTCH3 signaling pathway. J Tissue Eng Regen Med. 2021;15(2):103-115. DOI:10.1002/term.3149
TD-198946 Preparation Products And Raw materials
Raw materials
Preparation Products
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