ChemicalBook > CAS DataBase List > 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE

Product Name
2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
CAS No.
93249-62-8
Chemical Name
2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
Synonyms
BUTTPARK 22\04-61;5-(Trifloromethoxy)salicylaldehyde;5-(TRIFLUOROMETHOXY)SALICYLALDEHYDE;2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHY;5-(TrifluoroMethoxy)salicylaldehyde, 98+%;2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE;20HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE;Benzaldehyde, 2-hydroxy-5-(trifluoromethoxy)-;2-Hydroxy-5-(trifluoromethoxy)benzaldehyde99%;2-Hydroxy-5-(trifluoromethoxy)benzaldehyde 99%
CBNumber
CB9265660
Molecular Formula
C8H5F3O3
Formula Weight
206.12
MOL File
93249-62-8.mol
More
Less

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Property

Melting point:
31-33 °C (lit.)
Boiling point:
82 °C/60 mmHg (lit.)
Density 
1.4251 (estimate)
Flash point:
>230 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
7.56±0.18(Predicted)
form 
Low Melting Solid
color 
White to pale yellow
Sensitive 
Air Sensitive
BRN 
7023825
CAS DataBase Reference
93249-62-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29130000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
H977605
Product name
2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
H977605
Product name
2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-3-15
Product name
5-(Trifluoromethoxy)salicylaldehyde
Purity
99%
Packaging
5G
Price
$68
Updated
2021/12/16
AK Scientific
Product number
5778AC
Product name
2-Hydroxy-5-(trifluoromethoxy)benzaldehyde
Packaging
1g
Price
$77
Updated
2021/12/16
Matrix Scientific
Product number
005369
Product name
5-(Trifluoromethoxy)salicylaldehyde
Purity
95+%
Packaging
1g
Price
$21
Updated
2021/12/16
More
Less

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow low melting solid

Uses

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde may be used in the preparation of :

  • 2-[(E)-2-hydroxy-5-(trifluoromethoxy)benzylideneamino]-4-methylphenol
  • (E)-2-((3-fluorophenylimino)methyl)-4-(trifluoromethoxy) phenol
  • 2-[(E)-(naphthalen-2-ylimino) methyl]-4-(trifluoromethoxy) phenol

General Description

2-Hydroxy-5-(trifluoromethoxy)benzaldehyde is formed as intermediate during the biotransformation pathways of CP-122,721 in humans.

Synthesis

145742-65-0

93249-62-8

Step A: Boron tribromide (BBr3, 85.2 g, 341 mmol) was slowly added dropwise to a solution of 2-methoxy-5-(trifluoromethoxy)benzaldehyde (50.0 g, 227 mmol) in dichloromethane (DCM, 500 mL) at -20°C and under nitrogen protection. The reaction mixture was stirred at 0°C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of ice chips, followed by pouring the mixture into an aqueous solution of saturated sodium bicarbonate (NaHCO3, 300 mL) and extracting with dichloromethane (DCM, 3 x 400 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=20:1) to afford 2-hydroxy-5-(trifluoromethoxy)benzaldehyde (38.0 g, 81.0% yield). NMR hydrogen spectrum (400 MHz, CDCl3) δ 10.97 (s, 1H), 9.87 (s, 1H), 7.43-7.38 (m, 2H), 7.02 (d, J=8.0 Hz, 1H).

References

[1] Patent: WO2013/148851, 2013, A1. Location in patent: Paragraph 00244
[2] Patent: US2014/275172, 2014, A1. Location in patent: Paragraph 0842

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE Suppliers

Belgium 1 China 107 France 1 Germany 5 India 5 Switzerland 1 United Kingdom 19 United States 21 Global 160
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United States
ProdList
4583
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
SynQuest Laboratories, Inc. (Part of Central Glass Co., Ltd.)
Tel
--
Fax
--
Email
nfo@synquestlabs.com
Country
United States
ProdList
1897
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
eNovation Chemicals LLC
Tel
--
Fax
--
Email
ales@eNovationChem.com
Country
United States
ProdList
1673
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
More
Less

View Lastest Price from 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE manufacturers

Career Henan Chemical Co
Product
2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 93249-62-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

93249-62-8, 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDERelated Search:

2-METHOXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 2,5-bis(trifluoromethoxy)benzoic acid 2'-METHOXY-5'-(TRIFLUOROMETHOXY)ACETOPHENONE 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZOIC ACID 4-HYDROXY-3-(TRIFLUOROMETHOXY)BENZALDEHYDE 2-HYDROXY-3-(TRIFLUOROMETHOXY)BENZALDEHYDE Salicylaldehyde 1-(2-HYDROXY-5-TRIFLUOROMETHOXY-PHENYL)-ETHANONE 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZOYL CHLORIDE 2-HYDROXY-3-METHYL-5-(TRIFLUOROMETHOXY)BENZALDEHYDE 4-HYDROXY-2-(TRIFLUOROMETHOXY)BENZALDEHYDE 2-METHOXY-5-(TRIFLUOROMETHOXY)BENZAMIDE 5-BROMO-2-HYDROXY-3-(TRIFLUOROMETHOXY)BENZALDEHYDE BUTTPARK 35\07-36 2-HYDROXY-5-TRIFLUOROMETHOXYBENZOIC ACID ETHYL ESTER 6-Trifluoromethoxy-3,4-dihydro-2Hbenzo[1,4]oxazine-8-carboxylic acid methyl ester

  • BUTTPARK 22\04-61
  • 5-(TRIFLUOROMETHOXY)SALICYLALDEHYDE
  • 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
  • 5-(Trifloromethoxy)salicylaldehyde
  • 20HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHYDE
  • 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde 99%
  • 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde99%
  • 2-Hydroxy-5-(trifluoromethoxy)benzaldehyde, 98+%
  • 5-(Trifluoromethoxy)salicylaldehyde, 2-Formyl-4-(trifluoromethoxy)phenol
  • 5-(TrifluoroMethoxy)salicylaldehyde, 98+%
  • Benzaldehyde, 2-hydroxy-5-(trifluoromethoxy)-
  • 2-HYDROXY-5-(TRIFLUOROMETHOXY)BENZALDEHY
  • 93249-62-8
  • CF3OC6H3OHCHO
  • Aldehydes
  • Building Blocks
  • C8
  • Carbonyl Compounds
  • Organic Building Blocks
  • Aromatic Aldehydes & Derivatives (substituted)