ChemicalBook > CAS DataBase List > 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE

2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE

Product Name
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
CAS No.
6729-50-6
Chemical Name
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
Synonyms
2,3,4,5-tetrahydro-2-benzazepin-1-one;2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE;2,3,4,5-Tetrahydro-1H-2-benzazepin-1-one;2,3,4,5-tetrahydro-1H-2-benzazepine-1-one;1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-;2,3,4,5-Tetrahydro-benzo[c]azepin-1-one, CAS 6729-50-6
CBNumber
CB9265923
Molecular Formula
C10H11NO
Formula Weight
161.2
MOL File
6729-50-6.mol
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2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Property

Melting point:
99-100 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
Boiling point:
392.5±12.0 °C(Predicted)
Density 
1.100
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
14.78±0.20(Predicted)
Appearance
Off-white to light brown Solid
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Safety

Hazard Codes 
N
Risk Statements 
51/53
Safety Statements 
61
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements

H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS005171
Product name
2,3,4,5-tetrahydro-benzo[c]azepin-1-one
Purity
Aldrich<SUP>CPR</SUP>
Packaging
100 mg
Price
$73.1
Updated
2025/07/31
TRC
Product number
T310033
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Packaging
25mg
Price
$45
Updated
2021/12/16
TRC
Product number
T310033
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Packaging
50mg
Price
$60
Updated
2021/12/16
TRC
Product number
T310033
Product name
2,3,4,5-Tetrahydro-benzo[c]azepin-1-one
Packaging
250mg
Price
$130
Updated
2021/12/16
Matrix Scientific
Product number
139117
Product name
2,3,4,5-Tetrahydro-1H-benzo[c]azepin-1-one
Purity
95%+
Packaging
1g
Price
$182
Updated
2021/12/16
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2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Chemical Properties,Usage,Production

Chemical Properties

White to beige crystalline powder

Synthesis

529-34-0

6729-50-6

General procedure for the synthesis of 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one from 1-tetrahydronaphthalenone: 2.72 g (41.8 mmol) of sodium azide was added batchwise to a solution of concentrated hydrochloric acid (75 mL) containing 6.11 g (41.8 mmol) of 3,4-dihydronaphthalen-1(2H)-one and the reaction was carried out at 0 °C. Subsequently, the reaction was eluted with hydrochloric acid (75 mL) at 0 °C for 1 h. Stirring was continued at 0 °C for 30 min, then slowly warmed to room temperature and the reaction lasted for 16 hours. Upon completion of the reaction, the reaction mixture was poured into ice water and the pH was adjusted with potassium carbonate to 9. The aqueous phase was extracted with dichloromethane (DCM), the organic phases were combined and dried with anhydrous magnesium sulfate (MgSO?), filtered and concentrated under reduced pressure. The residue was purified by recrystallization from hexane. Further purification by column chromatography (silica gel, eluent hexane/ethyl acetate = 1:2) afforded 1.8 g (11.1 mmol, 27% yield) of the target product 2,3,4,5-tetrahydro-1H-2-benzazepin-1-one.

References

[1] Angewandte Chemie - International Edition, 2018, vol. 57, # 38, p. 12347 - 12351
[2] Angew. Chem., 2018, vol. 130, # 38, p. 12527 - 12531,5
[3] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 11, p. 914 - 919
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 13, p. 5287 - 5307
[5] Angewandte Chemie - International Edition, 2017, vol. 56, # 13, p. 3655 - 3659

2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE Suppliers

China 62 Germany 2 India 1 Switzerland 1 United Kingdom 2 United States 12 Global 80
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
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64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Atop-Pharma (Shanghai) Technology Co., Ltd.
Tel
+86 (21) 5196-9732
Fax
+86 (21) 5196-9733
Country
China
ProdList
996
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57
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2150
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55
NovoChemy Ltd.
Tel
021-31261262/ 49 (0)17662837245
Fax
(0)21-33250524
Email
sales@novochemy.com
Country
Germany
ProdList
6328
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
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56
Jiaxing Novartis Chemical Co., Ltd.
Tel
18957373295
Fax
-
Country
China
ProdList
1580
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58
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View Lastest Price from 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE manufacturers

Hebei Runbin Biotechnology Co. LTD
Product
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 6729-50-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99.9%
Supply Ability
20tons
Release date
2020-09-11
Career Henan Chemical Co
Product
2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 6729-50-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-07-09

6729-50-6, 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONERelated Search:

1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 8-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 3-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 7-METHOXY-2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE 7-METHOXY-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-BROMO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 8-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7,9-DIMETHYL-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 7-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 8-METHOXY-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-NITRO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 7-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE 8-AMINO-1,3,4,5-TETRAHYDRO-BENZO[B]AZEPIN-2-ONE 9-BROMO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE

  • 2,3,4,5-TETRAHYDRO-BENZO[C]AZEPIN-1-ONE
  • 2,3,4,5-Tetrahydro-1H-2-benzazepin-1-one
  • 2,3,4,5-tetrahydro-1H-2-benzazepine-1-one
  • 1H-2-Benzazepin-1-one, 2,3,4,5-tetrahydro-
  • 2,3,4,5-tetrahydro-2-benzazepin-1-one
  • 2,3,4,5-Tetrahydro-benzo[c]azepin-1-one, CAS 6729-50-6
  • 6729-50-6