2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE
- Product Name
- 2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE
- CAS No.
- 4370-22-3
- Chemical Name
- 2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE
- Synonyms
- Lansoprazole Impurity 49 HCl;-3-methylpyridine hydrochloride;2-(CHLOROMETHYL)-3-METHYLPYRIDINE HCL;2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE;Pyridine,2-(chloroMethyl)-3-Methyl-, hydrochloride;2-(chloromethyl)-3-methyl-Pyridine hydrochloride (1:1);Pyridine,2-(chloroMethyl)-3-Methyl-, hydrochloride (1:1)
- CBNumber
- CB9265943
- Molecular Formula
- C7H9Cl2N
- Formula Weight
- 178.06
- MOL File
- 4370-22-3.mol
2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE Property
- Melting point:
- 159℃ (isopropanol )
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C597970
- Product name
- 2-(Chloromethyl)-3-methylpyridinehydrochloride
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- FC141624
- Product name
- 2-(Chloromethyl)-3-methylpyridine hydrochloride
- Packaging
- 250mg
- Price
- $92.5
- Updated
- 2021/12/16
- Product number
- FC141624
- Product name
- 2-(Chloromethyl)-3-methylpyridine hydrochloride
- Packaging
- 500mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC141624
- Product name
- 2-(Chloromethyl)-3-methylpyridine hydrochloride
- Packaging
- 1g
- Price
- $281.25
- Updated
- 2021/12/16
- Product number
- 3H32-5-KL
- Product name
- 2-(Chloromethyl)-3-methylpyridinehydrochloride
- Purity
- 95%
- Packaging
- 1g
- Price
- $397
- Updated
- 2021/12/16
2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Synthesis
63071-09-0
4370-22-3
To a stirred solution of 2,3-dimethylpyridine (5.00 g, 46.7 mmol) in chloroform (100 mL) was added m-chloroperbenzoic acid (12.0 g, 77% max) in batches over a period of 5 min at 0 °C. The reaction mixture was continued to be stirred at 0 °C for 30 min, followed by slow warming to room temperature. After 16 hours of reaction, the mixture was concentrated to dryness, water (20 mL) was added and the pH was adjusted to 8 with saturated NaHCO3 solution. the mixture was concentrated again and the residue was extracted with dichloromethane/methanol (4:1). The organic phases were combined and concentrated to give a white solid. Purification by column chromatography (SiO2; eluent: dichloromethane/methanol, 9:1) afforded 2,3-dimethylpyridine-N-oxide as a white solid (4.80 g, 83% yield). The 2,3-dimethylpyridine-N-oxide (4.80 g, 39.0 mmol) was dissolved in acetic anhydride (50 mL) and heated to reflux overnight. After cooling, it was concentrated to dryness to give (2-acetoxymethyl)-3-methylpyridine as a brown oil (6.34 g). A mixture of crude (2-acetoxymethyl)-3-methylpyridine with K2CO3 (10.0 g, 72.4 mmol), methanol (60 mL) and water (30 mL) was stirred at room temperature overnight. The solid was removed by filtration and the filtrate was concentrated to dryness. After purification by column chromatography (SiO2; eluent: dichloromethane/methanol, 9:1), (2-hydroxymethyl)-3-methylpyridine was obtained as a light brown oil (2.86 g, 59% overall yield in two steps). The 1H NMR (CDCl3) data of (2-hydroxymethyl)-3-methylpyridine were as follows: δ 8.41 (d, J = 4.9 Hz, 1H), 7.48 (d, J = 7.5 Hz, 1H), 7.16 (dd, J = 4.9 and 7.5 Hz, 1H), 4.69 (s, 2H), 4.00 (br, 1H), 2.22 (s, 3H).
References
[1] Patent: WO2005/95360, 2005, A1. Location in patent: Page/Page column 58; 59
2-CHLOROMETHYL-3-METHYL-PYRIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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