2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

Product Name: 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
CAS No.: 117977-21-6
Chemical Name: 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole
Synonyms: rabeprazole sulphide;Rabeprazole Related CoMpound E;abeprazole Sulfide;Rabeprazole Sulfide;H 295/43;(+)-Limacine;Rabeprazole-3;(+)-Fangchinoline;Rabeprazole USP RC E;Rabeprazole Thioether
CBNumber: CB7102567
Molecular Formula: C18H21N3O2S
Formula Weight: 343.44
MOL File: 117977-21-6.mol

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2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Property

Melting point:: 120.5-121.50C
Boiling point:: 546.4±60.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 10.60±0.10(Predicted)
color: White to Off-White
InChI: InChI=1S/C18H21N3O2S/c1-13-16(19-9-8-17(13)23-11-5-10-22-2)12-24-18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
InChIKey: BSXAHDOWMOSVAP-UHFFFAOYSA-N
SMILES: C1(SCC2=NC=CC(OCCCOC)=C2C)NC2=CC=CC=C2N=1
CAS DataBase Reference: 117977-21-6(CAS DataBase Reference)

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Safety

HS Code: 2933998350

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3124
Product name: Rabeprazole Related Compound E
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $574
Updated: 2025/07/31

TCI Chemical

Product number: R0098
Product name: Rabeprazole Sulfide
Purity: >98.0%(HPLC)(T)
Packaging: 200mg
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: R0098
Product name: Rabeprazole Sulfide
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $129
Updated: 2025/07/31

TRC

Product number: R070510
Product name: Rabeprazole Sulfide
Packaging: 25mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: R0009-88C
Product name: Rabeprazole Thioether
Packaging: 5mg
Price: $425
Updated: 2021/12/16

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2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Chemical Properties,Usage,Production

Chemical Properties

Off-White Crystalline Powder

Uses

Rabeprazole Sulfide (Rabeprazole EP Impurity B) is a metabolite of Rabeprazole (R070500).

Synthesis

118175-10-3

134469-07-1

117977-21-6

General procedure for the synthesis of 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole from 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine and 1H-benzo[d]imidazole-2-thiol: 100 g of 2-hydroxymethyl-4-(3-methoxypropoxy)-3-methylpyridine ( 473.35 mmol) in a 2L three-necked flask, 1 L of tetrahydrofuran was added as solvent, followed by 71.10 g of 1H-benzo[d]imidazole-2-thiol (473.35 mmol) and 136.58 g of triphenylphosphine (520.69 mmol). Stirring was turned on and the reaction temperature was controlled at 0 °C. Slowly 90.678 g of diethyl azodicarboxylate (520.69 mmol) was added dropwise. After the dropwise addition, the reaction was maintained for 5h to 10h, during which the reaction progress was monitored by TLC. Upon completion of the reaction, the tetrahydrofuran was evaporated to dryness by rotary evaporator, and the resulting crude product was purified by recrystallization from methanol to give 130.0 g of the target product 2-[[[4-(3-methoxypropoxy)-3-methylpyrimidin-2-yl]methyl]thio]-1H-benzimidazole in 80% yield.

References

[1] Patent: CN106674198, 2017, A. Location in patent: Paragraph 0020-0021

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-20

Shaanxi Dideu New Materials Co. Ltd

Product: 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-10

Dideu Industries Group Limited

Product: 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole 117977-21-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-26

117977-21-6, 2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazoleRelated Search:

1-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]-2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole RaBeprazole Impurity H (S)-Rabeprazole Sodium Salt N-[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl] Rabeprazole Sulfone 1H-BENZIMIDAZOLE-2-SULFONIC ACID 4-Desmethoxypropoxyl-4-chloro Rabeprazole Sulfone 4-Desmethoxypropoxyl-4-chloro Rabeprazole 4-Nitro-2,3-lutidine-N-oxide Rabeprazole IMpurity G Rebeprazole sodium Rabeprazole 4-[(1H-Benzimidazol-2-yl)oxy]-3-methyl-2-pyridinecarboxylic Acid Discontinued See: B203960 Rabeprazole Impurity 2 2-[(4-Chloro-3-Methyl-2-Pyridinyl-methyl)thio]-1H-Benzimidazole Rabeprazole Impurity 2 Rabeprazole Related CoMpound A Rabeprazole Impurity 8 RABEPRAZOLE N-OXIDE

2-[(4-METHOXYPROPOXY-3-METHYL-2-PYRIDINYL)-METHYLTHIO]-BENZIMIDAZOLE

2-[[(3-METHYL-4-(3-METHOXYPROPOXY)PYRIDINYL)METHYL]THIO]-1H-BENZIMIDAZOLE

Rabeprazole IMpurity F

2-(((4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl)Methyl)thio)-1H-benzo[d]iMidazole

rabeprazole sulphide

2-[[4-(3-Methoxypropoxy)-3-Methyl-2-pyridyl]Methylthio]benziMidazole

Rabeprazole Sulfide IMpurity

2-[[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methylsulfanyl]-1h-benziMidazole

Rabeprazole Related Compound E (25 mg) (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole)

Rabeprazole USP RC E

Rabeprazole Related CoMpound E

Rabeprazole EP Impurity B

Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazole)

2-[[4-(3-Methoxypropoxy)-3-methyl-pyridin-2-yl]methylthio]benzoimidazole

2-[[(4-(3-Methoxypropoxy)- 3-methyl-2-pyridinyl)-2-methyl]thio]- 1H-benzimidazole

2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)

Rabeprazole Impurity 7

Rabeprazole Sodium Impurity Ⅲ:2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole

Rabeprazole EP Impurity B (Rabeprazole Sulfide)

Rabeprazole-3

2-[[[4-(3-Methoxypropoxy)-3-methylpyridinyl] methyl]thio]- 1H-benzimidazole (RabeSulphide)

Rabeprazole USP Related Compound E

2-[[[4-(3-Methoxypropoxy)-3-methylpiridine-2-yl]methyl]thio]-1H-benzimidazole

2-[[[4-(3-METHOXYPROPOXY)3-METHYL-2-PYRIDINYL] METHYL]THIO]1HBENZIMIDAZOLE

2-[[[4-(3-METHOXY PROPOXY)-3-METHYL PYRIDINE-2-YL]METHYL] THIO]-1H-BENZIMIDAZOLE

2-([4-(3-METHOXYPROPOXY)-3-METHYLPYRIDINE-2-YL]-METHYTHIO)1H-BENZIMIDAZOLE

2-[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYLTHIO}-1H-BENZIMIDAZOLE

2-[{4-(3-MethoxyPropoxy)-3-MethylPyridine-2-Yi}-Methylthio]-1H-Benzimidazole

H 295/43

2-[[[3-Methyl-4-(3-methoxypropoxy)-2-pyridyl]methyl]thio]-1H-benzimidazole

Rabeprazole Sulfide

Rabeprazole Thioether

2-{[4-(3-methoxypropoxy)-3-met

Rebeprazole thioether

1H-Benzimidazole, 2-[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]thio]-

2-(chloromethyl)-4-(3-methoxypropoxy)-3-methylpyridine hydro

2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-yl]Met

2-({[4-(3-Methoxypropoxy)-3-Methylpyridin-2-yl]Methyl}sulfanyl)-1H-1,3-benzodiazole

Rabeprazole Sulfide &gt

2-[[[4-(3-Methoxypropoxy)-3-methyl-

Rabeprazole Impurity 3（Rabeprazole EP Impurity B）

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole ISO 9001：2015 REACH

abeprazole Sulfide

Rabeprazole EP Impurity B/ Rabeprazole Related Compound E (Rabeprazole Sulfide)

Rabeprazole USP Related Compound E.doc

2-{[4-(3-Methoxypropoxy)-3-Methylpyridine-2-Yl]-Methythio}-1...

Rabeprazole sulphideQ: What is Rabeprazole sulphide Q: What is the CAS Number of Rabeprazole sulphide Q: What is the storage condition of Rabeprazole sulphide

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole/Rabeprazole sulfide

Rabeprazole Related Compound E (2-{[4-(3-Methoxypropoxy)-3-methyl-2-pyridyl]methylthio}benzimidazol (1598064)

(+)-Fangchinoline

(+)-Limacine

Rabeprazole Sulfide (Rabeprazole Impurity)

2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2- yl]methylthio}-1H-benzimidazole (Rabe Sulphide)

2-[[[4-(3-Methoxypropoxy)-3-Methylpyridinyl] Methyl]Thio]- 1H-Benzimidazole (Sulp)

2-(((4-(3-methoxypropoxy)-3-methylpyridine-2-yl) methyl) thio)-1H-benzo[d]imidazole

Ribeprazole condensate

2-[[[4-(3-Methoxy Propoxy-3-mthyl-2Pyridyl] Methyl]Thio]-1H-Benzimidazole

Rabeprazole Sulfide / Rabeprazole Related Compound-E