(4-Chloro-3-Methoxyphenyl)Methanol
- Product Name
- (4-Chloro-3-Methoxyphenyl)Methanol
- CAS No.
- 13726-17-5
- Chemical Name
- (4-Chloro-3-Methoxyphenyl)Methanol
- Synonyms
- 4-Chloro-3-methoxybenzyl alcohol;(4-Chloro-3-Methoxyphenyl)Methanol;Benzenemethanol, 4-chloro-3-methoxy-
- CBNumber
- CB92660959
- Molecular Formula
- C8H9ClO2
- Formula Weight
- 172.61
- MOL File
- 13726-17-5.mol
(4-Chloro-3-Methoxyphenyl)Methanol Property
- Boiling point:
- 279.2±25.0 °C(Predicted)
- Density
- 1.239±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.04±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2909498090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C372118
- Product name
- (4-chloro-3-methoxyphenyl)methanol
- Packaging
- 25g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- C372118
- Product name
- (4-chloro-3-methoxyphenyl)methanol
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC139974
- Product name
- (4-Chloro-3-methoxyphenyl)methanol
- Packaging
- 500mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- J96742
- Product name
- (4-Chloro-3-methoxyphenyl)methanol
- Packaging
- 5g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- FC139974
- Product name
- (4-Chloro-3-methoxyphenyl)methanol
- Packaging
- 5G
- Price
- $431
- Updated
- 2021/12/16
(4-Chloro-3-Methoxyphenyl)Methanol Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of Medicinal Chemistry, 32, p. 1757, 1989 DOI: 10.1021/jm00128a016
Synthesis
85740-98-3
13726-17-5
Step 1. Dissolve 4-chloro-3-methoxybenzoic acid (1.12 g, 5.98 mmol) in tetrahydrofuran (30 mL) under ice bath conditions with stirring. A tetrahydrofuran solution of 1.0 M lithium aluminum hydride (7.18 mL, 7.18 mmol) was slowly added over approximately 5 minutes. Ice bath conditions were maintained and stirring of the reaction mixture was continued for 2 hours. Upon completion of the reaction, the reaction was quenched by slow dropwise addition of water (0.27 mL), followed by addition of 15% aqueous sodium hydroxide solution (0.27 mL), and finally water (0.82 mL). The resulting suspension was filtered and the collected solid was washed with ethyl acetate. The filtrates were combined and concentrated under reduced pressure to give (4-chloro-3-methoxyphenyl)methanol as a colorless oil (737 mg, 71% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.92 (s, 3H), 4.67 (s, 2H), 6.87 (d, J = 7.6 Hz, 1H), 6.98 (s, 1H), 7.33 (d, J = 7.6 Hz, 1H).
References
[1] Patent: US2002/77486, 2002, A1
[2] Patent: US6906063, 2005, B2
[3] Patent: EP2314593, 2016, B1. Location in patent: Paragraph 0201
[4] Journal of Medicinal Chemistry, 1987, vol. 30, # 10, p. 1887 - 1891
[5] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4408 - 4414
(4-Chloro-3-Methoxyphenyl)Methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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