3-BROMO-5-HYDROXYBENZONITRILE
- Product Name
- 3-BROMO-5-HYDROXYBENZONITRILE
- CAS No.
- 770718-92-8
- Chemical Name
- 3-BROMO-5-HYDROXYBENZONITRILE
- Synonyms
- 3-BROMO-5-HYDROXYBENZONITRILE;Benzonitrile, 3-bromo-5-hydroxy-
- CBNumber
- CB92665282
- Molecular Formula
- C7H4BrNO
- Formula Weight
- 198.02
- MOL File
- 770718-92-8.mol
3-BROMO-5-HYDROXYBENZONITRILE Property
- Boiling point:
- 284.4±25.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.62±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- RIDADR
- 3439
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B613500
- Product name
- 3-Bromo-5-hydroxybenzonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 9386CX
- Product name
- 3-Bromo-5-hydroxybenzonitrile
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- BB20-3412
- Product name
- 3-Bromo-5-hydroxy-benzonitrile
- Purity
- ＞95%
- Packaging
- 0.5g
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CM117198
- Product name
- 3-Bromo-5-hydroxybenzonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $153
- Updated
- 2021/12/16
- Product number
- A198034
- Product name
- 3-Bromo-5-hydroxybenzonitrile
- Purity
- 98%
- Packaging
- 5g
- Price
- $300
- Updated
- 2021/12/16
3-BROMO-5-HYDROXYBENZONITRILE Chemical Properties,Usage,Production
Synthesis
867366-91-4
770718-92-8
General procedure for the synthesis of 3-hydroxy-5-bromobenzonitrile from 3-bromo-5-methoxybenzonitrile: Anhydrous colistin (100 mL) was added to a dry flask, followed by 3-bromo-5-methoxybenzonitrile (10.4 g, 49 mmol) and lithium iodide (LiI, 19.6 g, 3 equiv). The reaction mixture was heated to 150 °C and kept overnight under nitrogen protection. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice-cold 1 M hydrochloric acid (HCl) solution. The aqueous phase was extracted using a 1:1 mixture of ethyl acetate (EtOAc)/hexane and the organic phase was washed with water and dried with anhydrous magnesium sulfate (MgSO4). Finally, the target product 3-hydroxy-5-bromobenzonitrile (8.7 g, 89% yield) was obtained by vacuum concentration.
References
[1] Patent: US2005/239881, 2005, A1. Location in patent: Page/Page column 47-48
[2] Patent: US2008/20981, 2008, A1. Location in patent: Page/Page column 19
[3] Patent: US2008/45511, 2008, A1. Location in patent: Page/Page column 21
[4] Patent: US2008/293664, 2008, A1. Location in patent: Page/Page column 16
[5] Patent: US2008/249151, 2008, A1. Location in patent: Page/Page column 21
3-BROMO-5-HYDROXYBENZONITRILE Preparation Products And Raw materials
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