A 438079 (hydrochloride)
- Product Name
- A 438079 (hydrochloride)
- CAS No.
- 899431-18-6
- Chemical Name
- A 438079 (hydrochloride)
- Synonyms
- A-438079 HCl;A-438079;A438079;A 438079;3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride;P2X Receptor,A-438079,P2XRs,A 438079 hydrochloride,A438079,Inhibitor,inhibit,A 438079
- CBNumber
- CB92666582
- Molecular Formula
- C13H10Cl3N5
- Formula Weight
- 342.611
- MOL File
- 899431-18-6.mol
A 438079 (hydrochloride) Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- color
- White to off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 14580
- Product name
- A-438079 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $168
- Updated
- 2024/03/01
- Product number
- 14580
- Product name
- A-438079 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $570
- Updated
- 2024/03/01
- Product number
- 14580
- Product name
- A-438079 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2024/03/01
- Product number
- 14580
- Product name
- A-438079 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- D436095
- Product name
- 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridineHydrochloride
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
A 438079 (hydrochloride) Chemical Properties,Usage,Production
Description
A-
Uses
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine is a 1-Benzyl-5-aryltetrazole derivative and potential antagonists for the P2X7 receptor.
in vitro
In 1321N1 cells stably expressing rat P2X 7 receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC 50 of 321 nM. A 438079 is also selective for the P2X 7 receptor, at concentrations up to 100 μM.
in vivo
A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) signi?cantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but signi?cantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
storage
Desiccate at RT
References
Nelson et al. (2006) Structure-activity relationship studies on a series of novel, substitutes 1-benzyl-5-phenyltetrazole P2X7 antagonists; J. Med. Chem. 49 3659 McGaraughty et al. (2007) P2X7-related modulation of pathological nociception in rats; Neuroscience 146 1817 Clark et al. (2010) P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide; J. Neurosci. 30 573 Kobayashi et al. (201) Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model; Neurosci. Lett. 504 57 Chu et al. (2012) Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus; J. Neuroinflammation 9 69
A 438079 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
A 438079 (hydrochloride) Suppliers
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View Lastest Price from A 438079 (hydrochloride) manufacturers
- Product
- A 438079 (hydrochloride) 899431-18-6
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-28