Delafloxacin meglumine

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Delafloxacin meglumine

Physical Form

Product Name: Delafloxacin meglumine
CAS No.: 352458-37-8
Chemical Name: Delafloxacin meglumine
Synonyms: Delafloxcain meglumine;ABT 492 meglumine (Delafloxacin meglumine);100850;ABT492 MegluMine;ABT 492 MegluMine;ABT-492 MegluMine;RX-3341 meglumine;ABT-491 MegluMine;WQ-3034 meglumine);Delafloxacin Mcglumine
CBNumber: CB92666618
Molecular Formula: C25H29ClF3N5O9
Formula Weight: 635.98
MOL File: 352458-37-8.mol

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Delafloxacin meglumine Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in DMSO
form: Powder
color: Off-white to yellow
InChIKey: AHJGUEMIZPMAMR-KUAVVOKVNA-N
SMILES: [C@@H](O)([C@@H](O)CNC)[C@H](O)[C@H](O)CO.ClC1C(N2CC(O)C2)=C(F)C=C2C(=O)C(C(=O)O)=CN(C3N=C(N)C(F)=CC=3F)C=12 |&1:0,2,7,9,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27935
Product name: Delafloxacin (meglumine)
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 27935
Product name: Delafloxacin (meglumine)
Packaging: 250mg
Price: $1115
Updated: 2024/03/01

Cayman Chemical

Product number: 27935
Product name: Delafloxacin (meglumine)
Packaging: 50mg
Price: $270
Updated: 2024/03/01

Cayman Chemical

Product number: 27935
Product name: Delafloxacin (meglumine)
Packaging: 100mg
Price: $507
Updated: 2024/03/01

ApexBio Technology

Product number: A3357
Product name: Delafloxacinmeglumine
Packaging: 100mg
Price: $551
Updated: 2021/12/16

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Delafloxacin meglumine Chemical Properties,Usage,Production

Physical Form

Solid

Description

Delafloxacin meglumine (Baxdela, WQ-3034, ABT-492, RX-3341; Melinta Therapeutics) was approved by the U.S. Food and Drug Administration (FDA) in June 2017 for the treatment of acute bacterial skin and skin structure infections on the basis of data from two phase III trials.

Uses

Delafloxacin is a broad-spectrum anionic fluoroquinolone and its distinct chemical structure increases its potency in acidic environments. It is known to inhibit DNA replication and repair by targeting DNA gyrase and topoisomerase IV. Delafloxacin is administered via both oral and parenteral routes. It has potent activity against methicillin-resistant Staphylococcus aureus and Streptococci, and is also effective against Enterobacteriaceae and Pseudomonas aeruginosa.

Indications

Delafloxacin meglumine (Baxdelae Melinta) is a fluoroquinolone antibacterial agent with properties that are most similar to other members of this class, such as levofloxacin, moxifloxacin, and ciprofloxacin. It is supplied in formulations for oral and intravenous administration. It is indicated for the treatment of adults with ABSSSIs caused by susceptible isolates of the gram-positive bacteria Staphylococcus aureus (including methicillin-resistant [MRSA] and methicillin-susceptible isolates), Staphylococcus haemolyticus, Staphylococcus lugdunensis, Streptococcus agalactiae, Streptococcus anginosus group (including S. anginosus, S. intermedius, and S. constellatus), Streptococcus pyogenes, and Enterococcus faecalis, and the gram-negative bacteria Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, and Pseudomonas aeruginosa. It is the first fluoroquinolone to be demonstrated to be effective in the treatment of infections caused by MRSA, and its spectrum of antibacterial action, which also includes problem pathogens such as Pseudomonas aeruginosa, is broader than that of other antimicrobial agents that are indicated for the treatment of ABSSSIs[1].

Biological Activity

Delafloxacin meglumine (ABT492 meglumine; RX-3341 meglumine; WQ-3034 meglumine is a broad spectrum fluoroquinolone antibiotic. Delafloxacin has a wide range of activity against drug-resistant Staphylococcus aureus, Streptococcus pneumoniae and Klebsiella pneumoniae.

References

[1] Daniel A. Hussar, Molly A. Walter. “Delafloxacin meglumine, Meropenem trihydrate/vaborbactam, Secnidazole, and Benznidazole.” ACS Applied Bio Materials 58 2 (2018): Pages 223-227.

Delafloxacin meglumine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Delafloxacin meglumine manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Delafloxacin Meglumine 352458-37-8
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-08-05

Jinan Ande Pharmaceutical Co.,Ltd.

Product: Delafloxcain meglumine 352458-37-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100
Release date: 2021-12-18

Career Henan Chemical Co

Product: ABT-492 MegluMine 352458-37-8
Price: US $3.00/KG
Min. Order: 3KG
Purity: 98%
Supply Ability: 1kg,5kg,100kg
Release date: 2019-08-26

352458-37-8, Delafloxacin meglumineRelated Search:

Delafloxacin Impurity 2 Delafloxacin Dimer Impurity 2 NA NA Delafloxacin Impurity 8 Deschloro Delafloxacin Ethyl Ester Delafloxacin Dimer Impurity 1 Benzenepropanoic acid, α-[[(6-amino-3,5-difluoro-2-pyridinyl)amino]methylene]-3-chloro-2,4,5-trifluoro-β-oxo-, ethyl ester NA Delafloxacin Ethyl Ester 3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester NA NA Delafloxacin Impurity 7 Deschloro Delafloxacin DFSX-2 NA 3-quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-7-[3-[3-[[1-(6-amino-3,5-difluoro-2-pyridinyl)-3-carboxy-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl]amino]-2-hydroxypropoxy]-1-azetidinyl]-8-

100850

ABT 492 meglumine (Delafloxacin meglumine)

Delafloxacin meglumine (ABT492 meglumine

(2R,3R,4R,5S)-2,3,4,5-tetrahydroxy-6-(MethylaMino)hexyl 1-(6-aMino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

ABT 492 MegluMine

ABT492 MegluMine

ABT-492 MegluMine

Delafloxacin (MegluMine)

ABT-492MegluMine/ABT492MegluMine

(2R,3R,4R,5S)-6-(MethylaMino)hexane-1,2,3,4,5-pentaol 1-(6-aMino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylate

(2R,3R,4R,5S)-2,3,4,5-Tetrahydroxy-6-(methylamino)hexyl 1-(6-amino-3,5-difluoropyridin-2-yl)-8

Delafloxacin meglumine (Synonyms: ABT492 meglumine

RX-3341 meglumine

WQ-3034 meglumine)

D-Glucitol, 1-deoxy-1-(methylamino)-, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylate (1:1)

ABT492 MEGLUMINE; ABT-492 MEGLUMINE; DELAFLOXACIN MEGLUMINE

Delafloxcain meglumine

ABT-491 MegluMine

(2R,3R,4R,5S)-2,3,4,5-Tetrahydroxy-6-(methylamino)hexyl 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquin

Delafloxacin Mcglumine

elafloxcain Delafloxcain meglumine

ethyl(3R)-piperidine-9-carboxylate

Delafloxacin meglumine Impurity

Delafloxacin meglumine, 10 mM in DMSO

352458-37-8

C18H12ClF3N4O4C7H17NO5

C25H29ClF3N5O9

C25H27ClF3N5O8

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