ChemicalBook > CAS DataBase List > PDK1 Inhibitor

PDK1 Inhibitor

Product Name: PDK1 Inhibitor
CAS No.: 850717-64-5
Chemical Name: PDK1 Inhibitor
Synonyms: BX-517;BIX517;CS-1693;BX517 ，S6504;BX-517;BX 517;PDK1 Inhibitor 2;PDK1 Inhibitor II;BX517, 10 mM in DMSO;BX517(PDK1 inhibitor2);inhibit,BX517,Inhibitor,PDK-1
CBNumber: CB92667655
Molecular Formula: C15H14N4O2
Formula Weight: 282.3
MOL File: 850717-64-5.mol

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PDK1 Inhibitor Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥8.55 mg/mL in DMSO
form: solid
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 521276
Product name: PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem
Packaging: 5mg
Price: $167
Updated: 2023/01/07

Cayman Chemical

Product number: 29238
Product name: BX-517
Packaging: 5mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 29238
Product name: BX-517
Packaging: 50mg
Price: $648
Updated: 2024/03/01

Cayman Chemical

Product number: 29238
Product name: BX-517
Packaging: 10mg
Price: $195
Updated: 2024/03/01

Cayman Chemical

Product number: 29238
Product name: BX-517
Packaging: 25mg
Price: $352
Updated: 2024/03/01

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PDK1 Inhibitor Chemical Properties,Usage,Production

Uses

BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).

Biological Activity

bx-517 is a potent and selective inhibitor of pdk1 that binds to the atp binding pocketof the protein (ic50 = 6 nm). bx-517 also blocks activation of akt in tumor cells with 10-fold more potent (ic50 = 0.1–1.0 μm) than its analogs tested at the highest dose tested (10 μm). [1] the phosphoinositide-dependent kinase-1 (pdk1) is a ser/thr kinase that is a crucial activator of a range of protein kinases in the agc kinase super-family that play key roles in the progression of cancer and for the activation of akt, s6 kinase, and protein kinase c. [2]

References

1. islam i, brown g, bryant j et al. indolinone based phosphoinositide-dependentkinase-1 (pdk1) inhibitors. part 2: optimization of bx-517. bioorg med chem lett.2007 jul 15;17(14):3819-25. 2. islam i, bryant j, chou yl etc. indolinone based phosphoinositide-dependent kinase-1 (pdk1)inhibitors. part 1: design, synthesis and biological activity. bioorg med chem lett. 2007 jul 15;17(14):3814-8.

PDK1 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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850717-64-5, PDK1 InhibitorRelated Search:

BX-517

BX517(PDK1 inhibitor2)

5-Ureido-3-[1-(pyrrol-2-yl)ethylidene]indolin-2-one

PDK1 Inhibitor 2

CS-1693

PDK1 Inhibitor II

BX-517;BX 517

Urea, [2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-

Urea, N-[2,3-dihydro-2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-1H-indol-5-yl]-

2-Oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]indolin-5-yl]urea,BX-517

inhibit,BX517,Inhibitor,PDK-1

BIX517

{2-oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]-2,3-dihydro-1H-indol-5-yl}urea

BX517, 10 mM in DMSO

BX517 ，S6504

850717-64-5