PDK1 Inhibitor
- Product Name
- PDK1 Inhibitor
- CAS No.
- 850717-64-5
- Chemical Name
- PDK1 Inhibitor
- Synonyms
- BX-517;BIX517;CS-1693;BX-517;BX 517;PDK1 Inhibitor 2;PDK1 Inhibitor II;BX517(PDK1 inhibitor2);inhibit,BX517,Inhibitor,PDK-1;5-Ureido-3-[1-(pyrrol-2-yl)ethylidene]indolin-2-one;2-Oxo-3-[1-(1H-pyrrol-2-yl)ethylidene]indolin-5-yl]urea,BX-517
- CBNumber
- CB92667655
- Molecular Formula
- C15H14N4O2
- Formula Weight
- 282.3
- MOL File
- 850717-64-5.mol
PDK1 Inhibitor Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥8.55 mg/mL in DMSO
- form
- solid
- color
- Light yellow to khaki
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 521276
- Product name
- PDK1 Inhibitor II - CAS 850717-64-5 - Calbiochem
- Packaging
- 5mg
- Price
- $167
- Updated
- 2023/01/07
- Product number
- 29238
- Product name
- BX-517
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 29238
- Product name
- BX-517
- Packaging
- 50mg
- Price
- $648
- Updated
- 2024/03/01
- Product number
- 29238
- Product name
- BX-517
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
- Product number
- 29238
- Product name
- BX-517
- Packaging
- 25mg
- Price
- $352
- Updated
- 2024/03/01
PDK1 Inhibitor Chemical Properties,Usage,Production
Uses
BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
Biological Activity
bx-517 is a potent and selective inhibitor of pdk1 that binds to the atp binding pocketof the protein (ic50 = 6 nm). bx-517 also blocks activation of akt in tumor cells with 10-fold more potent (ic50 = 0.1–1.0 μm) than its analogs tested at the highest dose tested (10 μm). [1] the phosphoinositide-dependent kinase-1 (pdk1) is a ser/thr kinase that is a crucial activator of a range of protein kinases in the agc kinase super-family that play key roles in the progression of cancer and for the activation of akt, s6 kinase, and protein kinase c. [2]
References
1. islam i, brown g, bryant j et al. indolinone based phosphoinositide-dependentkinase-1 (pdk1) inhibitors. part 2: optimization of bx-517. bioorg med chem lett.2007 jul 15;17(14):3819-25. 2. islam i, bryant j, chou yl etc. indolinone based phosphoinositide-dependent kinase-1 (pdk1)inhibitors. part 1: design, synthesis and biological activity. bioorg med chem lett. 2007 jul 15;17(14):3814-8.
PDK1 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
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