SKLB1002

ChemicalBook > CAS DataBase List > SKLB1002

Product Name: SKLB1002
CAS No.: 1225451-84-2
Chemical Name: SKLB1002
Synonyms: CS-1002;SKLB1002;SKLB1002 USP/EP/BP;SKLB 1002; SKLB-1002;6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline;2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole;Quinazoline, 6,7-dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-;6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline SKLB 1002
CBNumber: CB92667958
Molecular Formula: C13H12N4O2S2
Formula Weight: 320.39
MOL File: 1225451-84-2.mol

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SKLB1002 Property

Melting point:: 193 °C
Boiling point:: 522.4±60.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥5 mg/mL in EtOH with gentle warming and ultrasonic; ≥8 mg/mL in DMSO
form: powder to crystal
pka: -0.14±0.30(Predicted)
color: White to Light yellow

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Safety

HS Code: 2934.99.3900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: K0060
Product name: SKLB1002
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $94
Updated: 2024/03/01

TCI Chemical

Product number: K0060
Product name: SKLB1002
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $255
Updated: 2024/03/01

TRC

Product number: S555000
Product name: SKLB1002
Packaging: 25mg
Price: $270
Updated: 2021/12/16

Usbiological

Product number: 466168
Product name: SKLB1002
Packaging: 5mg
Price: $340
Updated: 2021/12/16

Chem-Impex

Product number: 42396
Product name: SKLB1002,≥98%(HPLC)
Purity: ≥98%(HPLC)
Packaging: 100MG
Price: $295.86
Updated: 2021/12/16

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SKLB1002 Chemical Properties,Usage,Production

Uses

SKLB1002 is a potent vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor that inhibits angiogenesis and tumor growth in vivo.

Biological Activity

sklb1002 is a potent inhibitor of vegf receptor 2 with ic50 value of 32 nm [1].vegf receptor 2 (vegfr2) is a major receptor for vascular endothelial growth factor (vegf) and plays an important role in angiogenesis and vegf-stimulated proliferation, migration, and sprouting of cultured endothelial cells [1].sklb1002 is a potent vegfr2 inhibitor. in human umbilical vein endothelial cells (huvec), sklb1002 significantly inhibited vegf-induced huvec proliferation with ic50 value of 11.9 μm. also, sklb1002 inhibited huvec migration, invasion and tube formation in a dose-dependent way. sklb1002 (10 μm) significantly inhibited vegf-induced phosphorylation of vegfr2, erk, src and fak [1].in zebrafish embryos, sklb1002 (2.5 μm) significantly inhibited the growth of intersegmental vessels. in mice bearing sw620 or hepg2 xenografts, sklb1002 (100 mg/kg) significantly inhibited tumor volume and inhibited tumor growth by 60%. also, sklb1002 reduced the microvessel density [1]. in mice with 4t1 tumor, sklb1002 significantly reduced the tumor vessel density [2].

target

VEGFR2

References

[1]. zhang s, cao z, tian h, et al. sklb1002, a novel potent inhibitor of vegf receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. clin cancer res, 2011, 17(13): 4439-4450.
[2]. shen g, li y, du t, et al. sklb1002, a novel inhibitor of vegf receptor 2 signaling, induces vascular normalization to improve systemically administered chemotherapy efficacy. neoplasma, 2012, 59(5): 486-493.

SKLB1002 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SKLB1002 manufacturers

Career Henan Chemical Co

Product: SKLB1002 1225451-84-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-23

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SKLB1002

2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole

6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline

6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline SKLB 1002

CS-1002

SKLB 1002; SKLB-1002

Quinazoline, 6,7-dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-

SKLB1002 USP/EP/BP

1225451-84-2

Inhibitors