SKLB1002
- Product Name
- SKLB1002
- CAS No.
- 1225451-84-2
- Chemical Name
- SKLB1002
- Synonyms
- CS-1002;SKLB1002;SKLB1002 USP/EP/BP;SKLB 1002; SKLB-1002;6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline;2-((6,7-diMethoxyquinazolin-4-yl)thio)-5-Methyl-1,3,4-thiadiazole;Quinazoline, 6,7-dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-;6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]quinazoline SKLB 1002
- CBNumber
- CB92667958
- Molecular Formula
- C13H12N4O2S2
- Formula Weight
- 320.39
- MOL File
- 1225451-84-2.mol
SKLB1002 Property
- Melting point:
- 193 °C
- Boiling point:
- 522.4±60.0 °C(Predicted)
- Density
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- insoluble in H2O; ≥5 mg/mL in EtOH with gentle warming and ultrasonic; ≥8 mg/mL in DMSO
- form
- powder to crystal
- pka
- -0.14±0.30(Predicted)
- color
- White to Light yellow
Safety
- HS Code
- 2934.99.3900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- K0060
- Product name
- SKLB1002
- Purity
- >98.0%(HPLC)
- Packaging
- 25mg
- Price
- $94
- Updated
- 2024/03/01
- Product number
- K0060
- Product name
- SKLB1002
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $255
- Updated
- 2024/03/01
- Product number
- S555000
- Product name
- SKLB1002
- Packaging
- 25mg
- Price
- $270
- Updated
- 2021/12/16
- Product number
- 466168
- Product name
- SKLB1002
- Packaging
- 5mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 42396
- Product name
- SKLB1002,≥98%(HPLC)
- Purity
- ≥98%(HPLC)
- Packaging
- 100MG
- Price
- $295.86
- Updated
- 2021/12/16
SKLB1002 Chemical Properties,Usage,Production
Uses
SKLB1002 is a potent vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor that inhibits angiogenesis and tumor growth in vivo.
Biological Activity
sklb1002 is a potent inhibitor of vegf receptor 2 with ic50 value of 32 nm [1].vegf receptor 2 (vegfr2) is a major receptor for vascular endothelial growth factor (vegf) and plays an important role in angiogenesis and vegf-stimulated proliferation, migration, and sprouting of cultured endothelial cells [1].sklb1002 is a potent vegfr2 inhibitor. in human umbilical vein endothelial cells (huvec), sklb1002 significantly inhibited vegf-induced huvec proliferation with ic50 value of 11.9 μm. also, sklb1002 inhibited huvec migration, invasion and tube formation in a dose-dependent way. sklb1002 (10 μm) significantly inhibited vegf-induced phosphorylation of vegfr2, erk, src and fak [1].in zebrafish embryos, sklb1002 (2.5 μm) significantly inhibited the growth of intersegmental vessels. in mice bearing sw620 or hepg2 xenografts, sklb1002 (100 mg/kg) significantly inhibited tumor volume and inhibited tumor growth by 60%. also, sklb1002 reduced the microvessel density [1]. in mice with 4t1 tumor, sklb1002 significantly reduced the tumor vessel density [2].
target
VEGFR2
References
[1]. zhang s, cao z, tian h, et al. sklb1002, a novel potent inhibitor of vegf receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo. clin cancer res, 2011, 17(13): 4439-4450.
[2]. shen g, li y, du t, et al. sklb1002, a novel inhibitor of vegf receptor 2 signaling, induces vascular normalization to improve systemically administered chemotherapy efficacy. neoplasma, 2012, 59(5): 486-493.
SKLB1002 Preparation Products And Raw materials
Raw materials
Preparation Products
SKLB1002 Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28398
- Advantage
- 80
View Lastest Price from SKLB1002 manufacturers
- Product
- SKLB1002 1225451-84-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 85.0-99.8%
- Supply Ability
- 20 tons
- Release date
- 2019-12-23