ChemicalBook > CAS DataBase List > CCT 244747

CCT 244747

Product Name
CCT 244747
CAS No.
1404095-34-6
Chemical Name
CCT 244747
Synonyms
CS-1625;CCT 244747;CCT-244747; CCT 244747;CCT244747; CCT-244747; CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
CBNumber
CB92668551
Molecular Formula
C20H24N8O2
Formula Weight
408.46
MOL File
1404095-34-6.mol
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CCT 244747 Property

Boiling point:
562.6±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
pka
8.15±0.28(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25666
Product name
CCT244747
Purity
≥98%
Packaging
1mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
25666
Product name
CCT244747
Purity
≥98%
Packaging
5mg
Price
$207
Updated
2024/03/01
Cayman Chemical
Product number
25666
Product name
CCT244747
Purity
≥98%
Packaging
10mg
Price
$341
Updated
2024/03/01
Biosynth Carbosynth
Product number
FD145154
Product name
3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
Packaging
5mg
Price
$390
Updated
2021/12/16
ApexBio Technology
Product number
B5880
Product name
CCT244747
Packaging
10mg
Price
$394
Updated
2021/12/16
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CCT 244747 Chemical Properties,Usage,Production

Description

CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.

in vitro

cct244747 inhibited cellular chk1 activity, significantly enhanced the cytotoxicity of a few anticancer drugs and abrogated drug-induced s and g2 arrest in multiple tumor cell lines. biomarkers of chk1 activity and cell cycle inactivity were induced by genotoxics and inhibited by cct244747, producing enhanced dna damage and apoptosis [1].

in vivo

active tumor concentrations of cct244747 were obtained following oral administration. the antitumor activities of both gemcitabine and irinotecan were significantly enhanced by cct244747 in human tumor xenografts, giving concomitant biomarker modulation indicative of chk1 inhibition [1].

IC 50

29-170 nm

References

[1] walton mi, eve pd, hayes a, valenti mr, de haven brandon ak, box g, hallsworth a, smith el, boxall kj, lainchbury m, matthews tp, jamin y, robinson sp, aherne gw, reader jc, chesler l, raynaud fi, eccles sa, collins i, garrett md. cct244747 is a novel potent and selective chk1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. clin cancer res. 2012 oct 15;18(20):5650-61.

CCT 244747 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT 244747 Suppliers

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1404095-34-6, CCT 244747Related Search:

6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE Naquotinib (mesylate) HS-173 BI-9564 BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide 4-Propylphenol

  • CCT244747; CCT-244747; CCT 244747
  • CS-1625
  • CCT 244747
  • 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • 3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile
  • CCT-244747; CCT 244747
  • 2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
  • 1404095-34-6
  • C20H24N8O2