ChemicalBook > CAS DataBase List > CCT 244747

CCT 244747

Product Name: CCT 244747
CAS No.: 1404095-34-6
Chemical Name: CCT 244747
Synonyms: CS-1625;CCT 244747;CCT-244747; CCT 244747;CCT244747; CCT-244747; CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
CBNumber: CB92668551
Molecular Formula: C20H24N8O2
Formula Weight: 408.46
MOL File: 1404095-34-6.mol

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CCT 244747 Property

Boiling point:: 562.6±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
pka: 8.15±0.28(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25666
Product name: CCT244747
Purity: ≥98%
Packaging: 1mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 25666
Product name: CCT244747
Purity: ≥98%
Packaging: 5mg
Price: $207
Updated: 2024/03/01

Cayman Chemical

Product number: 25666
Product name: CCT244747
Purity: ≥98%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FD145154
Product name: 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
Packaging: 5mg
Price: $390
Updated: 2021/12/16

ApexBio Technology

Product number: B5880
Product name: CCT244747
Packaging: 10mg
Price: $394
Updated: 2021/12/16

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CCT 244747 Chemical Properties,Usage,Production

Description

CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC₅₀ = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC₅₀s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G₂/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G₂ checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.

Uses

CCT244747 is a potent, orally bioavailable and highly selective CHK1 inhibitor, with an IC50 of 7.7 nM; CCT244747 also abrogates G2 checkpoint with an IC50 of 29 nM.

in vitro

cct244747 inhibited cellular chk1 activity, significantly enhanced the cytotoxicity of a few anticancer drugs and abrogated drug-induced s and g2 arrest in multiple tumor cell lines. biomarkers of chk1 activity and cell cycle inactivity were induced by genotoxics and inhibited by cct244747, producing enhanced dna damage and apoptosis [1].

in vivo

active tumor concentrations of cct244747 were obtained following oral administration. the antitumor activities of both gemcitabine and irinotecan were significantly enhanced by cct244747 in human tumor xenografts, giving concomitant biomarker modulation indicative of chk1 inhibition [1].

IC 50

29-170 nm

References

[1] walton mi, eve pd, hayes a, valenti mr, de haven brandon ak, box g, hallsworth a, smith el, boxall kj, lainchbury m, matthews tp, jamin y, robinson sp, aherne gw, reader jc, chesler l, raynaud fi, eccles sa, collins i, garrett md. cct244747 is a novel potent and selective chk1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. clin cancer res. 2012 oct 15;18(20):5650-61.

CCT 244747 Preparation Products And Raw materials

Raw materials

Preparation Products

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CCT 244747 Suppliers

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1404095-34-6, CCT 244747Related Search:

Asciminib 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE Naquotinib (mesylate) HS-173 BI-9564 BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- 4-Propylphenol

CCT244747; CCT-244747; CCT 244747

CS-1625

CCT 244747

3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile

3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile

CCT-244747; CCT 244747

2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-

1404095-34-6

C20H24N8O2