ethyl 3-hydroxy-1H-pyrazole-4-carboxylate
- Product Name
- ethyl 3-hydroxy-1H-pyrazole-4-carboxylate
- CAS No.
- 7251-53-8
- Chemical Name
- ethyl 3-hydroxy-1H-pyrazole-4-carboxylate
- Synonyms
- Allopurinol Impurity 10;4-(Ethoxycarbonyl)-3-hydroxy-1H-pyrazole;ehyl 3-hydroxy-1H-pyrazole-4-carboxylate;ethyl 3-hydroxy-1H-pyrazole-4-carboxylate;Ethyl 5-hydroxy-1H-pyrazole-4-carboxylate;ethyl 3-oxo-1,2-dihydropyrazole-4-carboxylate;Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate 95%;ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate;Ethyl 2,3-dihydro-3-oxo-1H-pyrazole-4-carboxylate;2,3-dihydro-3-oxo-1H-Pyrazole-4-carboxylic acid ethyl ester
- CBNumber
- CB92671454
- Molecular Formula
- C6H8N2O3
- Formula Weight
- 156.14
- MOL File
- 7251-53-8.mol
ethyl 3-hydroxy-1H-pyrazole-4-carboxylate Property
- Melting point:
- 140-142 °C
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.78±0.70(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C6H8N2O3/c1-2-11-6(10)4-3-7-8-5(4)9/h3H,2H2,1H3,(H2,7,8,9)
- InChIKey
- PJFXDPZWCVXNQZ-UHFFFAOYSA-N
- SMILES
- N1C=C(C(OCC)=O)C(=O)N1
Safety
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- E925613
- Product name
- Ethyl3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CS-W018871
- Product name
- Ethyl3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
- Purity
- 99.85%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 059088
- Product name
- 3-Hydroxy-1H-pyrazole-4-carboxylic acidethyl ester
- Purity
- 95%+
- Packaging
- 1g
- Price
- $94
- Updated
- 2021/12/16
- Product number
- 4H29-1-16
- Product name
- Ethyl 3-hydroxy-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- CS-W018871
- Product name
- Ethyl3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate
- Purity
- 99.85%
- Packaging
- 5g
- Price
- $193
- Updated
- 2021/12/16
ethyl 3-hydroxy-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
87-13-8
7251-53-8
Synthesis of ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate: Hydrazine monohydrate (10.0 mL, 0.20 mol) was slowly added to an ethanolic solution (400 mL) of sodium ethoxide (20.8 g, 0.31 mol) and diethyl ethoxymethylenemalonate (20 mL, 0.10 mol) under the cooling condition of ice-water bath. Subsequently, the reaction mixture was heated to reflux at 80 °C for 3 hours. Upon completion of the reaction, the mixture was diluted with water (200 mL) and the pH was adjusted to 6 with 10 M HCl solution. separation was carried out by multiple extractions with chloroform. The aqueous phase was further acidified to pH 2 and extracted again with chloroform. All organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product. The crude product was washed with methanol and ethyl ether and dried to afford the target compound ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate (13.2 g, 80% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.89 (s, 1H), 4.15 (q, J = 7.12 Hz, 2H), 1.23 (t, J = 7.11 Hz, 3H).
References
[1] Patent: WO2009/89057, 2009, A1. Location in patent: Page/Page column 56
[2] Patent: WO2016/83816, 2016, A1. Location in patent: Page/Page column 48
[3] Patent: EP3272750, 2018, A1. Location in patent: Paragraph 0219; 0220
[4] Yakugaku Zasshi, 1957, vol. 77, p. 800
[5] Chem.Abstr., 1957, p. 17893
ethyl 3-hydroxy-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
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View Lastest Price from ethyl 3-hydroxy-1H-pyrazole-4-carboxylate manufacturers
- Product
- ethyl 3-hydroxy-1H-pyrazole-4-carboxylate 7251-53-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10tons
- Release date
- 2020-02-18
- Product
- ethyl 3-hydroxy-1H-pyrazole-4-carboxylate 7251-53-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-09