Ganoderic acid D
- Product Name
- Ganoderic acid D
- CAS No.
- 108340-60-9
- Chemical Name
- Ganoderic acid D
- Synonyms
- Ganoderic acid D-RM;Ganoderic acid D, 10 mM in DMSO;(7beta)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid;Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)-;cyclophilin,colon,CypD,Ganoderic acid D,human,Apoptosis,inhibit,oxygenated,Sirtuin,tetracyclic,cancer,carcinoma,HeLa,triterpenoid,Inhibitor,deacetylated,cervical
- CBNumber
- CB92672936
- Molecular Formula
- C30H42O7
- Formula Weight
- 514.65
- MOL File
- 108340-60-9.mol
Ganoderic acid D Property
- Boiling point:
- 688.3±55.0 °C(Predicted)
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C, protect from light
- solubility
- Soluble in methanol;
- form
- powder
- pka
- 4.77±0.23(Predicted)
- color
- White
- Water Solubility
- insoluble in water
N-Bromosuccinimide Price
- Product number
- SML3612
- Product name
- Ganoderic acid D
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $106.4
- Updated
- 2025/07/31
- Product number
- SML3612
- Product name
- Ganoderic acid D
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $451
- Updated
- 2025/07/31
- Product number
- PHL84214
- Product name
- Ganoderic acid D
- Purity
- phyproof?ReferenceSubstance
- Packaging
- 10MG
- Price
- $470
- Updated
- 2025/07/31
- Product number
- 26765
- Product name
- Ganoderic Acid D
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 26765
- Product name
- Ganoderic Acid D
- Packaging
- 25mg
- Price
- $661
- Updated
- 2024/03/01
Ganoderic acid D Chemical Properties,Usage,Production
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from the dried fruiting body of Ganoderma lucidum (Leyss. exFr.) Karst. of the Polyporaceae family.
Uses
Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D induces HeLa human cervical carcinoma apoptosis[2].
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Ganoderic acid D is one of major triterpenes isolated from Ganoderma lucidum th at exhibit potent anticancer properties. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate, and pyruvate and acetyl-coenzyme production through SIRT3 upregulation via acetylated cyclophilin D inhibition.
IC 50
SIRT3
References
[1] Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77. DOI:10.1016/j.ejphar.2018.01.026
[2] Yue QX, et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61. DOI:10.1074/mcp.M700259-MCP200
Ganoderic acid D Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ganoderic acid D manufacturers
- Product
- Ganoderic acid D 108340-60-9
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-08
- Product
- ganoderic acid D 108340-60-9
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09