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Nilotinib hydrochloride anhydrous

Product Name
Nilotinib hydrochloride anhydrous
CAS No.
923288-95-3
Chemical Name
Nilotinib hydrochloride anhydrous
Synonyms
Nilotinib hydrochloride;AMN-107 HCl;Nilotinib HCI;Nilotinib hydrochloride anhydrou;Nilotinib hydrochloride anhydrous;Nilotinib hydrochloride, 10 mM in DMSO;Nilotinib hydrochloride anhydrous USP/EP/BP;4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide hydrochloride (1:1)
CBNumber
CB92676787
Molecular Formula
C28H23ClF3N7O
Formula Weight
565.99
MOL File
923288-95-3.mol
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Nilotinib hydrochloride anhydrous Property

storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (176.68 mM);Ethanol: 2 mg/mL (3.53 mM)
Water Solubility 
Water: Insoluble
InChIKey
VTGGYCCJUPYZSX-UHFFFAOYSA-N
SMILES
C(NC1=CC(C(F)(F)F)=CC(N2C=C(C)N=C2)=C1)(=O)C1=CC=C(C)C(NC2=NC=CC(C3=CC=CN=C3)=N2)=C1.Cl
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H360May damage fertility or the unborn child

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
N465290
Product name
NilotinibHydrochloride
Packaging
250mg
Price
$205
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0027469
Product name
NILOTINIB HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$452.67
Updated
2021/12/16
Axon Medchem
Product number
Axon3168
Product name
Nilotinibhydrochloride-AMN107hydrochloride
Purity
99%
Packaging
10mg
Price
$77
Updated
2021/12/16
Axon Medchem
Product number
Axon3168
Product name
Nilotinibhydrochloride-AMN107hydrochloride
Purity
99%
Packaging
50mg
Price
$154
Updated
2021/12/16
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Nilotinib hydrochloride anhydrous Chemical Properties,Usage,Production

Uses

Nilotinib Hydrochloride might be useful in treatment of chronic myelogenous leukemia. It is a COVID19-related research product.

in vivo

Nilotinib hydrochloride (oral gavage, 40 mg/kg, daily, 4 weeks) shows equivalent or higher antitumor effects in BALB/cSLc-nu/nu mice with GIST xenograft[2].
Nilotinib hydrochloride has a significant healing effect on the macroscopic and microscopic pathologic scores and ensures considerable mucosal healing in the indomethacin-induced enterocolitis rat model while decreases the PDGFR α and β levels and apoptotic scores in the colon[3].

Animal Model:BALB/cSLc-nu/nu mice with GIST xenograft (GK1X, GK2X and GK3X)[2]
Dosage:40 mg/kg
Administration:Oral gavage; daily; 4 weeks
Result:Inhibited tumor growth by 69.6% in GK1X, 85.3% in GK2X and 47.5% in GK3X xenograft line.

Nilotinib hydrochloride anhydrous Preparation Products And Raw materials

Raw materials

Preparation Products

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Nilotinib hydrochloride anhydrous Suppliers

China 56 India 10 Israel 1 United States 5 Global 72
Pharma Affiliates
Tel
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Email
@pharmaffiliates.com
Country
India
ProdList
6754
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Agati Healthcare Private Limited
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India
ProdList
2
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58
SynZeal Research Pvt Ltd
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Email
standards@synzeal.com
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India
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6514
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Pharmaffiliates Analytics and Synthetics P. Ltd
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Email
mktg@pharmaffiliates.com
Country
India
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6739
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MSN LABORATORIES PRIVATE LTD
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info@msnlabs.com
Country
India
ProdList
230
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DR REDDYS LABORATORIES LTD
Tel
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Fax
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Email
krishnaraoy@drreddys.com
Country
India
ProdList
201
Advantage
58
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View Lastest Price from Nilotinib hydrochloride anhydrous manufacturers

Baoji Guokang Healthchem co.,ltd
Product
Nilotinib hydrochloride anhydrous 923288-95-3
Price
US $16.00/g
Min. Order
1g
Purity
99%
Supply Ability
10kgs
Release date
2021-06-07
Dideu Industries Group Limited
Product
Nilotinib hydrochloride anhydrous 923288-95-3
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-18

923288-95-3, Nilotinib hydrochloride anhydrousRelated Search:

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  • Nilotinib hydrochloride anhydrous
  • Nilotinib hydrochloride
  • 4-Methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-{[4-(3-pyridinyl)-2-pyrimidinyl]amino}benzamide hydrochloride (1:1)
  • AMN-107 HCl
  • Nilotinib hydrochloride anhydrou
  • Nilotinib hydrochloride anhydrous USP/EP/BP
  • Nilotinib HCI
  • Nilotinib hydrochloride, 10 mM in DMSO
  • 923288-95-3
  • C28H23ClF3N7O