2-Bromo-6-(difluoromethyl)pyridine

Product Name: 2-Bromo-6-(difluoromethyl)pyridine
CAS No.: 872365-91-8
Chemical Name: 2-Bromo-6-(difluoromethyl)pyridine
Synonyms: 2-Bromo-6-(difluoromethyl)pyridine;Pyridine, 2-bromo-6-(difluoromethyl)-;2-Bromo-6-(difluoromethyl)pyridine 95%;2-Bromo-6-(difluoromethyl)pyridine 95+%;6-Bromo-alpha,alpha-difluoro-2-picoline
CBNumber: CB92688340
Molecular Formula: C6H4BrF2N
Formula Weight: 208
MOL File: 872365-91-8.mol

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2-Bromo-6-(difluoromethyl)pyridine Property

Density: 1.703 g/mL at 25 °C
refractive index: 1.520
Flash point:: 110℃
storage temp.: 2-8°C
form: liquid
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C6H4BrF2N/c7-5-3-1-2-4(10-5)6(8)9/h1-3,6H
InChIKey: ZTBGDNNRDRISQZ-UHFFFAOYSA-N
SMILES: C1(Br)=NC(C(F)F)=CC=C1

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2810 6.1 / PGIII
WGK Germany: 3
HazardClass: 6.1
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 741302
Product name: 2-Bromo-6-(difluoromethyl)pyridine
Purity: 95%
Packaging: 1g
Price: $53.5
Updated: 2025/07/31

TRC

Product number: B699780
Product name: 2-Bromo-6-(difluoromethyl)pyridine
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: 1187AF
Product name: 2-Bromo-6-(difluoromethyl)pyridine
Packaging: 1g
Price: $116
Updated: 2021/12/16

Apolloscientific

Product number: PC49145
Product name: 2-Bromo-6-(difluoromethyl)pyridine
Purity: 95+%
Packaging: 5g
Price: $127
Updated: 2021/12/16

Apolloscientific

Product number: PC49145
Product name: 2-Bromo-6-(difluoromethyl)pyridine
Purity: 95+%
Packaging: 1g
Price: $28
Updated: 2021/12/16

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2-Bromo-6-(difluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

34160-40-2

872365-91-8

Step 3. Preparation of 2-bromo-6-(difluoromethyl)pyridine To a solution of 6-bromopyridine-2-carbaldehyde (2.10 g, 11.29 mmol) in dichloromethane (20 mL) was slowly added diethylamino sulfur trifluoride (1.94 mL, 14.68 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the mixture was carefully poured into pre-cooled saturated sodium bicarbonate solution (300 mL). Extraction was carried out with ethyl acetate (2 x 120 mL) and the organic phases were combined. Subsequently, the organic phase was washed sequentially with saturated sodium bicarbonate solution (80 mL) and brine (2 x 50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to afford 2-bromo-6-(difluoromethyl)pyridine as a brown oil (2.17 g, 89% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.75-7.70 (m, 1H), 7.65-7.60 (m, 2H), 6.60 (t, J = 55.1 Hz, 1H).

References

[1] Patent: WO2017/201468, 2017, A1. Location in patent: Page/Page column 236
[2] Patent: WO2017/80979, 2017, A1. Location in patent: Page/Page column 124; 125
[3] Patent: US2009/253750, 2009, A1. Location in patent: Page/Page column 9
[4] Patent: US2016/221998, 2016, A1. Location in patent: Paragraph 0396; 0397

2-Bromo-6-(difluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-6-(difluoromethyl)pyridine Suppliers

China 55 India 1 United Kingdom 1 United States 6 Global 63

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View Lastest Price from 2-Bromo-6-(difluoromethyl)pyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Bromo-6-(difluoromethyl)pyridine 872365-91-8
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

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872365-91-8