ChemicalBook > CAS DataBase List > 2-Bromo-6-(difluoromethyl)pyridine

2-Bromo-6-(difluoromethyl)pyridine

Product Name
2-Bromo-6-(difluoromethyl)pyridine
CAS No.
872365-91-8
Chemical Name
2-Bromo-6-(difluoromethyl)pyridine
Synonyms
2-Bromo-6-(difluoromethyl)pyridine;Pyridine, 2-bromo-6-(difluoromethyl)-;2-Bromo-6-(difluoromethyl)pyridine 95%;2-Bromo-6-(difluoromethyl)pyridine 95+%;6-Bromo-alpha,alpha-difluoro-2-picoline
CBNumber
CB92688340
Molecular Formula
C6H4BrF2N
Formula Weight
208
MOL File
872365-91-8.mol
More
Less

2-Bromo-6-(difluoromethyl)pyridine Property

Density 
1.703 g/mL at 25 °C
refractive index 
1.520
Flash point:
110℃
storage temp. 
2-8°C
form 
liquid
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C6H4BrF2N/c7-5-3-1-2-4(10-5)6(8)9/h1-3,6H
InChIKey
ZTBGDNNRDRISQZ-UHFFFAOYSA-N
SMILES
C1(Br)=NC(C(F)F)=CC=C1
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2810 6.1 / PGIII
WGK Germany 
3
HazardClass 
6.1
HS Code 
2933399990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
741302
Product name
2-Bromo-6-(difluoromethyl)pyridine
Purity
95%
Packaging
1g
Price
$53.5
Updated
2025/07/31
TRC
Product number
B699780
Product name
2-Bromo-6-(difluoromethyl)pyridine
Packaging
500mg
Price
$110
Updated
2021/12/16
AK Scientific
Product number
1187AF
Product name
2-Bromo-6-(difluoromethyl)pyridine
Packaging
1g
Price
$116
Updated
2021/12/16
Apolloscientific
Product number
PC49145
Product name
2-Bromo-6-(difluoromethyl)pyridine
Purity
95+%
Packaging
5g
Price
$127
Updated
2021/12/16
Apolloscientific
Product number
PC49145
Product name
2-Bromo-6-(difluoromethyl)pyridine
Purity
95+%
Packaging
1g
Price
$28
Updated
2021/12/16
More
Less

2-Bromo-6-(difluoromethyl)pyridine Chemical Properties,Usage,Production

Synthesis

34160-40-2

872365-91-8

Step 3. Preparation of 2-bromo-6-(difluoromethyl)pyridine To a solution of 6-bromopyridine-2-carbaldehyde (2.10 g, 11.29 mmol) in dichloromethane (20 mL) was slowly added diethylamino sulfur trifluoride (1.94 mL, 14.68 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 18 hours. Upon completion of the reaction, the mixture was carefully poured into pre-cooled saturated sodium bicarbonate solution (300 mL). Extraction was carried out with ethyl acetate (2 x 120 mL) and the organic phases were combined. Subsequently, the organic phase was washed sequentially with saturated sodium bicarbonate solution (80 mL) and brine (2 x 50 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to afford 2-bromo-6-(difluoromethyl)pyridine as a brown oil (2.17 g, 89% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.75-7.70 (m, 1H), 7.65-7.60 (m, 2H), 6.60 (t, J = 55.1 Hz, 1H).

References

[1] Patent: WO2017/201468, 2017, A1. Location in patent: Page/Page column 236
[2] Patent: WO2017/80979, 2017, A1. Location in patent: Page/Page column 124; 125
[3] Patent: US2009/253750, 2009, A1. Location in patent: Page/Page column 9
[4] Patent: US2016/221998, 2016, A1. Location in patent: Paragraph 0396; 0397

2-Bromo-6-(difluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-Bromo-6-(difluoromethyl)pyridine Suppliers

China 55 India 1 United Kingdom 1 United States 6 Global 63
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
More
Less

View Lastest Price from 2-Bromo-6-(difluoromethyl)pyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Bromo-6-(difluoromethyl)pyridine 872365-91-8
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-17

872365-91-8, 2-Bromo-6-(difluoromethyl)pyridineRelated Search:

2-Bromo-6-(trifluoromethyl)pyridine

  • 2-Bromo-6-(difluoromethyl)pyridine
  • 6-Bromo-alpha,alpha-difluoro-2-picoline
  • 2-Bromo-6-(difluoromethyl)pyridine 95%
  • 2-Bromo-6-(difluoromethyl)pyridine 95+%
  • Pyridine, 2-bromo-6-(difluoromethyl)-
  • 872365-91-8