ChemicalBook > CAS DataBase List > 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline

Product Name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
CAS No.: 959795-70-1
Chemical Name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Synonyms: Naquotinib intermediate;1,3-Propanediol,1-(7-piperidinyl)-;4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline;4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzenamine;Benzenamine, 4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-;4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine
CBNumber: CB92693292
Molecular Formula: C16H26N4
Formula Weight: 274.4
MOL File: 959795-70-1.mol

Less

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Property

Boiling point:: 447.2±45.0 °C(Predicted)
Density: 1.114±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 8.14±0.42(Predicted)
Appearance: Off-white to gray Solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: M330485
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Packaging: 1g
Price: $210
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389600
Product name: 4-(4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL)ANILINE
Purity: 95.00%
Packaging: 5MG
Price: $502.93
Updated: 2021/12/16

Matrix Scientific

Product number: 096682
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Purity: 95+%
Packaging: 250mg
Price: $742
Updated: 2021/12/16

AK Scientific

Product number: 6715AC
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Packaging: 25g
Price: $1605
Updated: 2021/12/16

Matrix Scientific

Product number: 096682
Product name: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline
Purity: 95+%
Packaging: 1g
Price: $1647
Updated: 2021/12/16

Less

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Chemical Properties,Usage,Production

Uses

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline acts as a reagent in the preparation of Gilteritinib derivatives as inhibitors of FLT3-Axl.

Synthesis

959795-69-8

959795-70-1

GENERAL METHOD: 1-methyl-4-(1-(4-nitrophenyl)piperidin-4-yl)piperazine (2.18 g, 6.52 mmol) was dissolved in ethanol (50 mL) and 10% palladium carbon (wet basis, 53% water; 600 mg) was added. The reaction mixture was stirred at room temperature and 1 atm hydrogen atmosphere for 8 hours. Upon completion of the reaction, the insoluble material was removed by Celite filtration and the filtrate was concentrated under vacuum to afford 4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline (1.96 g, 99%) as a light purple solid.

References

[1] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 3, p. 251 - 262
[2] Patent: US2009/318441, 2009, A1. Location in patent: Page/Page column 45
[3] European Journal of Medicinal Chemistry, 2019, p. 690 - 709

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline Suppliers

China 53 India 2 United States 4 Global 59

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chengdu Firster Pharmaceutical Co., Ltd.

Tel: 028-87078428 028-87074958
Fax: 8772-8116
Email: chengzhenyong@cdfirster.com
Country: China
ProdList: 2598
Advantage: 60

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 10410
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shanghai Rlavie Technology Co., Ltd.

Tel: 21-67759270 17717059219
Fax: QQ：1479352695
Email: sales@rlavie.com
Country: China
ProdList: 1620
Advantage: 55

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Suzhou Rovathin Foreign Trade Co.,Ltd

Tel: 0512-65816829 18662214788
Fax: 0512-65816829
Email: info@rovathin.com.cn
Country: China
ProdList: 9987
Advantage: 58

Jinan Baizhou Biological Technology Co., Ltd.

Tel: 0531-88987162 18615427082
Email: 2823799053@qq.com
Country: China
ProdList: 544
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Jiaozuo Vaughan Biotechnology Co., Ltd.

Tel: 0391-3702345 18739121806
Email: sales@wnbiopharm.com
Country: China
ProdList: 829
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39927
Advantage: 58

Shanghai Payne Pharmaceutical Technology Co.Ltd

Tel: 021-58123769 17721400256
Email: info@paynepharm.com
Country: China
ProdList: 1285
Advantage: 58

Shanghai Payne Pharmaceutical Technology Co.Ltd

Tel: 021-58123769 18678586262
Email: info@paynepharm.com
Country: China
ProdList: 1354
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Beijing Haite lesk Technology Co., Ltd

Tel: 15210893940; 15116916250
Fax: QQ: 237008221
Email: chemistryliu@163.com
Country: China
ProdList: 7327
Advantage: 58

Birdo (Shanghai) Medical Technology Co., Ltd.

Tel: 021-58099077-8041 18601625411
Email: sales@birdotech.com
Country: China
ProdList: 9764
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengdrug@163.com; 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20009
Advantage: 58

Zhengzhou Convergence Chemical Co. LTD

Tel: 0371-0371-53736046 13393710386
Fax: QQ:2853979814
Email: 2853979814@qq.com
Country: China
ProdList: 9948
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Shanghai Lingfu Pharmaceutical Research Co. LTD

Tel: +86(21)5895 0110 19945755304
Email: sales@chemany.com
Country: China
ProdList: 9984
Advantage: 58

Jiaxing Deyi Chemical Co., Ltd

Tel: 0573-85866609 13588473046
Email: 824930988@qq.com
Country: China
ProdList: 7865
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Tengjun Biotechnology Co. LTD

Tel: 19821570922
Email: angela@labgogo.com
Country: China
ProdList: 9896
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: sales@pharmablock.com
Country: China
ProdList: 7268
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-81145305 17791533577
Email: 1021@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Shaoyuan Technology (Shanghai) Co., Ltd.

Tel: 021-50795510 4000665055
Email: sy-c6@accelachem.com
Country: China
ProdList: 10000
Advantage: 58

Hangzhou Sulfuchem Material Technology Co., Ltd.

Tel: 0571-86113725 15372021306
Email: sales@sulfuchem.com
Country: China
ProdList: 970
Advantage: 58

Shanghai Daken Advanced Materials Co.,Ltd

Tel: +86-2158073036
Email: info@dakenam.com
Country: China
ProdList: 13595
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Email: sales@coreychem.com
Country: China
ProdList: 29847
Advantage: 58

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Shenzhen Nexconn Pharmatechs Ltd

Tel: +86-755-89396905 +86-15013857715
Email: admin@nexconn.com
Country: China
ProdList: 10405
Advantage: 58

Guangzhou Jinling Biotechnology Co., Ltd.

Tel: 15017560539
Country: CHINA
ProdList: 142
Advantage: 58

Shanghai Machine Pure Industrial Co., Ltd.

Tel: --
Fax: --
Email: 3245176082@qq.com
Country: CHINA
ProdList: 6800
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6650
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6184
Advantage: 58

Xiamen Research Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1562893815@qq.com
Country: CHINA
ProdList: 6936
Advantage: 58

Less

View Lastest Price from 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline manufacturers

Career Henan Chemical Co

Product: 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline 959795-70-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-04

959795-70-1, 4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)anilineRelated Search:

4-(4-Methylpiperazino)aniline 4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-1-nitrobenzene 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile

4-(4-(4-Methylpiperazin-1-yl)piperidin-1-yl)aniline

Naquotinib intermediate

4-[4-(4-Methyl-piperazin-1-yl)-piperidin-1-yl]-phenylamine

4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]benzenamine

Benzenamine, 4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]-

1,3-Propanediol,1-(7-piperidinyl)-

959795-70-1