Rubitecan

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Description Reference

Product Name: Rubitecan
CAS No.: 91421-42-0
Chemical Name: Rubitecan
Synonyms: 9-NC;RFS 2000;Oratheci;orathecin;RUBITECAN;RUBETICAN;Rubitecane;9-NITRO-CPT;9-Nitrocamptothecin;Rubitecan USP/EP/BP
CBNumber: CB9270138
Molecular Formula: C20H15N3O6
Formula Weight: 393.35
MOL File: 91421-42-0.mol

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Rubitecan Property

Melting point:: 182-186°C
alpha: D23 +27° (c = 0.2 in CH3OH-CHCl3, 1:4)
Boiling point:: 816.3±65.0 °C(Predicted)
Density: 1.63
Flash point:: 106℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO, Chloroform, Methanol
form: Solid
pka: 11.16±0.20(Predicted)
color: Yellow
Merck: 14,8288
CAS DataBase Reference: 91421-42-0(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: UQ0493300
HS Code: 29399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R3655
Product name: Rubitecan
Packaging: 10mg
Price: $56.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: R3655
Product name: Rubitecan
Packaging: 50mg
Price: $225
Updated: 2024/03/01

TCI Chemical

Product number: N0822
Product name: 9-Nitrocamptothecin
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $273
Updated: 2024/03/01

Cayman Chemical

Product number: 28956
Product name: Rubitecan
Packaging: 10mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 28956
Product name: Rubitecan
Packaging: 25mg
Price: $112
Updated: 2024/03/01

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Rubitecan Chemical Properties,Usage,Production

Description

Rubitecan, marketed by Supergen as Orathecin, is a promising oral treatment for solid melanoma, prostate, breast, ovarian, and other cancers, as well as leukemia. It is a derivative of camptothecin, a topoisomerase inhibitor known from Chinese Traditional Medicine. It selectively targets the critical S-stage of cellular reproduction – particularly in acidic environments, as in many cancer cells – relaxing DNA supercoiling and generating lethal breaks in the DNA. Due to insolubility, its biological delivery mechanism is not yet effective, and it has not been approved for clinical use.

Reference

https://www.sciencedirect.com/topics/medicine-and-dentistry/rubitecan
https://en.wikipedia.org/wiki/Rubitecan
https://en.wikipedia.org/wiki/Topoisomerase_inhibitor
https://en.wikipedia.org/wiki/Camptothecin#cite_note-Y.Pommier_2003-14
https://www.ncbi.nlm.nih.gov/pubmed/1995300

Description

Rubitecan is a DNA topoisomerase I inhibitor. It inhibits DNA topoisomerase I and increases the fraction of supercoiled DNA in a cell-free assay in a concentration-dependent manner. Rubitecan inhibits the growth of A121 ovarian and H460 lung cancer cells (IC₅₀s = 4 and 2 nM, respectively). It also inhibits the growth of doxorubicin-susceptible and -resistant MCF-7 breast cancer cells (IC₅₀s = 2 and 3 nM, respectively). Rubitecan (4 mg/kg twice per week) reduces tumor growth in a U937 leukemia mouse xenograft model.

Chemical Properties

Yellow Amorphous Powder

Uses

Semisynthetic camptothecin which inhibits DNA topoisomerase I. Prodrug of 9-aminocamptothecin. Antineoplastic.

Definition

ChEBI: A pyranoindolizinoquinoline that is camptothecin in which the hydrogen at position 9 has been replaced by a nitro group. It is a prodrug for 9-aminocamptothecin.

Rubitecan Preparation Products And Raw materials

Raw materials

Preparation Products

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Rubitecan Suppliers

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View Lastest Price from Rubitecan manufacturers

Hebei Duling International Trade Co. LTD

Product: Rubitecan 91421-42-0
Price: US $23.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2023-01-06

Henan Aochuang Chemical Co.,Ltd.

Product: Rubitecan 91421-42-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Dideu Industries Group Limited

Product: Rubitecan 91421-42-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

91421-42-0, RubitecanRelated Search:

(+)-Camptothecin 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-9-methoxy-, (4S)- SN-38-D3 7-Ethyl-20(R)-camptothecin daurisoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one L-Hyoscyamine Xanthiazone VERATRINE veratramine VERATRIDINE menisdaurin Daurinoline Xanthiside 9-Aminocamptothecin 20R-Camptothecin Camptothecin 7-ETHYL-10-HYDROXYCAMPTOTHECIN,98%

RFS 2000

9-Nitrocellulose camptothecine

9-NITRO-CPT

9-NITRO-20(S)-CAMPTOTHECIN

(4s)-4-ethyl-4-hydroxy-10-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione

RUBETICAN

RUBITECAN

orathecin

CAMPTOTHECIN, 9-NITRO-20(S)-

Rubitecane

(4S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[346,7]indolizinol[1,2-b]quinoline-3,14(4H,-12H)-dione

9-NC

Oratheci

Rubitecan (RFS 2000)

9-Nitrocamptothecin (Rubitecan)

9-Nitrocamptothecin

9-Nitrocamptothecin&gt

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-nitro-, (4S)-

Rubitecan USP/EP/BP

Camptothecin Impurity 13

CAMPTOTHECIN, 9-NITRO-20

(S)-4-Ethyl-4-hydroxy-10-nitro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

91421-42-0

C20H15N3O6

Anti-cancer & immunity

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Intermediates & Fine Chemicals

Pharmaceuticals