ChemicalBook > CAS DataBase List > 1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine

1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine

Product Name
1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine
CAS No.
877399-34-3
Chemical Name
1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine
Synonyms
1-Boc-3-(4-bromo-1-pyrazolyl)azetidine;1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine;1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine - [B10912];tert-Butyl 3-(4-bromopyrazol-1-yl)azetidine-1-carboxylate;tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(4-bromo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
CBNumber
CB92704039
Molecular Formula
C11H16BrN3O2
Formula Weight
302.17
MOL File
877399-34-3.mol
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1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Property

storage temp. 
2-8°C
form 
solid
Appearance
White to off-white Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHB00155
Product name
1-Boc-3-(4-bromo-1H-pyrazol-1-yl)azetidine
Purity
AldrichCPR
Packaging
1 g
Price
$330
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
HCH0419576
Product name
TERT-BUTYL-3-(4-BROMO-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$456.7
Updated
2021/12/16
Matrix Scientific
Product number
122195
Product name
1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine
Purity
97.0%
Packaging
1g
Price
$660
Updated
2021/12/16
Synthonix
Product number
B10912
Product name
1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine
Purity
97.0%
Packaging
5g
Price
$790
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-9-3G
Product name
tert-Butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate
Purity
97.0%
Packaging
1g
Price
$900
Updated
2021/12/16
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1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Chemical Properties,Usage,Production

Synthesis

2075-45-8

141699-58-3

877399-34-3

N-Boc-3-methylsulfonyloxyazetidine (304 mg, 1.21 mmol), 4-bromopyrazole (178 mg, 1.21 mmol), a mineral oil suspension of 60% NaH (73 mg, 1.82 mmol), and 2 mL of DMF were added to the microwave tube.The reaction mixture was microwaved at 110 °C for 30 min. Upon completion of the reaction, the mixture was partitioned between EtOAc (200 mL) and saturated NaHCO3 solution (2 × 50 mL) and washed with brine (50 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 360 mg of the yellow oily product tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate in 98% yield.1H NMR (400 MHz, DMSO-D6) δ ppm 1.36-1.43 (m, 9H), 4.08 (s, 2H), 4.18- 4.31 (m, 2H), 5.12-5.22 (m, 1H), 7.67 (s, 1H), 8.14 (s, 1H).

References

[1] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 57-58
[2] Patent: WO2006/21881, 2006, A2. Location in patent: Page/Page column 62-63; 64
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 - 6363

1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Suppliers

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877399-34-3, 1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidineRelated Search:

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