1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine
- Product Name
- 1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine
- CAS No.
- 877399-34-3
- Chemical Name
- 1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine
- Synonyms
- 1-Boc-3-(4-bromo-1-pyrazolyl)azetidine;1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine;1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine - [B10912];tert-Butyl 3-(4-bromopyrazol-1-yl)azetidine-1-carboxylate;tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate;1-Azetidinecarboxylic acid, 3-(4-bromo-1H-pyrazol-1-yl)-, 1,1-dimethylethyl ester
- CBNumber
- CB92704039
- Molecular Formula
- C11H16BrN3O2
- Formula Weight
- 302.17
- MOL File
- 877399-34-3.mol
1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Property
- storage temp.
- 2-8°C
- form
- solid
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- PHB00155
- Product name
- 1-Boc-3-(4-bromo-1H-pyrazol-1-yl)azetidine
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $330
- Updated
- 2025/07/31
- Product number
- HCH0419576
- Product name
- TERT-BUTYL-3-(4-BROMO-1H-PYRAZOL-1-YL)AZETIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $456.7
- Updated
- 2021/12/16
- Product number
- 122195
- Product name
- 1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $660
- Updated
- 2021/12/16
- Product number
- B10912
- Product name
- 1-Boc-3-(4-Bromo-1H-pyrazol-1-yl)azetidine
- Purity
- 97.0%
- Packaging
- 5g
- Price
- $790
- Updated
- 2021/12/16
- Product number
- 4H56-9-3G
- Product name
- tert-Butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $900
- Updated
- 2021/12/16
1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Chemical Properties,Usage,Production
Synthesis
2075-45-8
141699-58-3
877399-34-3
N-Boc-3-methylsulfonyloxyazetidine (304 mg, 1.21 mmol), 4-bromopyrazole (178 mg, 1.21 mmol), a mineral oil suspension of 60% NaH (73 mg, 1.82 mmol), and 2 mL of DMF were added to the microwave tube.The reaction mixture was microwaved at 110 °C for 30 min. Upon completion of the reaction, the mixture was partitioned between EtOAc (200 mL) and saturated NaHCO3 solution (2 × 50 mL) and washed with brine (50 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 360 mg of the yellow oily product tert-butyl 3-(4-bromo-1H-pyrazol-1-yl)azetidine-1-carboxylate in 98% yield.1H NMR (400 MHz, DMSO-D6) δ ppm 1.36-1.43 (m, 9H), 4.08 (s, 2H), 4.18- 4.31 (m, 2H), 5.12-5.22 (m, 1H), 7.67 (s, 1H), 8.14 (s, 1H).
References
[1] Patent: US2006/46991, 2006, A1. Location in patent: Page/Page column 57-58
[2] Patent: WO2006/21881, 2006, A2. Location in patent: Page/Page column 62-63; 64
[3] Journal of Medicinal Chemistry, 2011, vol. 54, # 18, p. 6342 - 6363
1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Boc-3-(4-BroMo-1H-pyrazol-1-yl)azetidine Suppliers
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