3-Chloro-1H-pyrazol-5-aMine
- Product Name
- 3-Chloro-1H-pyrazol-5-aMine
- CAS No.
- 916211-79-5
- Chemical Name
- 3-Chloro-1H-pyrazol-5-aMine
- Synonyms
- EOS-61385;5-chloro-1H-pyrazol-3-aMine;3-Chloro-1H-pyrazol-5-aMine;5-Chloro-1H-Pyrazole-3-amine;1H-Pyrazol-3-amine, 5-chloro-
- CBNumber
- CB92704307
- Molecular Formula
- C3H4ClN3
- Formula Weight
- 117.54
- MOL File
- 916211-79-5.mol
3-Chloro-1H-pyrazol-5-aMine Property
- Boiling point:
- 394.0±22.0 °C(Predicted)
- Density
- 1.562±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 12.32±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C3H4ClN3/c4-2-1-3(5)7-6-2/h1H,(H3,5,6,7)
- InChIKey
- HLMGWUFWDSUGRU-UHFFFAOYSA-N
- SMILES
- N1C(Cl)=CC(N)=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0050541
- Product name
- 5-Chloro-1H-pyrazol-3-amine
- Purity
- 99.01%
- Packaging
- 250mg
- Price
- $40
- Updated
- 2021/12/16
- Product number
- CS-0050541
- Product name
- 5-Chloro-1H-pyrazol-3-amine
- Purity
- 99.01%
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- HCH0419673
- Product name
- 5-CHLORO-1H-PYRAZOL-3-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.8
- Updated
- 2021/12/16
- Product number
- CS-0050541
- Product name
- 5-Chloro-1H-pyrazol-3-amine
- Purity
- 99.01%
- Packaging
- 10g
- Price
- $514
- Updated
- 2021/12/16
- Product number
- CS-0050541
- Product name
- 5-Chloro-1H-pyrazol-3-amine
- Purity
- 99.01%
- Packaging
- 5g
- Price
- $314
- Updated
- 2021/12/16
3-Chloro-1H-pyrazol-5-aMine Chemical Properties,Usage,Production
Synthesis
1369959-12-5
916211-79-5
The general procedure for the synthesis of 5-chloro-1H-pyrazol-3-amine from 3-chloro-5-nitro-1H-pyrazole was as follows: tin(II) chloride (12.8 g, 68 mmol) was added batchwise to a methanol (200 mL) solution of 3-chloro-5-nitro-1H-pyrazole (2.0 g, 13.6 mmol). Concentrated hydrochloric acid (10 mL) was added slowly at 0°C. The reaction mixture was stirred at room temperature for 6 h. The organic solvent was subsequently removed by distillation under reduced pressure. The residue was diluted with distilled water (20 mL) and neutralized with sodium carbonate (Na2CO3) to pH 7. Subsequently, extraction was carried out with ethyl acetate (EtOAc, 3 × 50 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford 5-chloro-1H-pyrazol-3-amine (1.4 g, 87% yield), which was used for subsequent reactions without further purification. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 11.55 (broad single peak, 1H), 5.26 (single peak, 2H), 5.21 (single peak, 1H).
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3036 - 3048
[2] Patent: WO2018/85247, 2018, A1. Location in patent: Paragraph 00296; 00300
3-Chloro-1H-pyrazol-5-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloro-1H-pyrazol-5-aMine manufacturers
- Product
- 3-Chloro-1H-pyrazol-5-aMine 916211-79-5
- Price
- US $1.50/g
- Min. Order
- 1g
- Purity
- 99.0% Min
- Supply Ability
- 100 Tons
- Release date
- 2025-09-25
- Product
- 3-Chloro-1H-pyrazol-5-aMine 916211-79-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2018-08-19