2-(3-broMophenyl)-2-oxoacetic acid

2-(3-broMophenyl)-2-oxoacetic acid Property

Melting point:

60-61 °C

Boiling point:

329.4±34.0 °C(Predicted)

Density 

1.738±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

pka

2.10±0.54(Predicted)

Appearance

White to off-white Solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

2-(3-broMophenyl)-2-oxoacetic acid Chemical Properties,Usage,Production

Synthesis

General procedure for the synthesis of 2-(3-bromophenyl)-2-oxoacetic acid from ethyl 2-(3-bromophenyl)-2-oxoacetate: to a solution of ethyl 2-(3-bromophenyl)-2-oxoacetate (1 g, 3.9 mmol) in methanol (10 mL) was added an aqueous solution of potassium hydroxide (2 mL, 50% w/v) and the reaction mixture was stirred at room temperature for 30 min. Upon completion of the reaction, the pH was adjusted to 4 with 1 N hydrochloric acid. the reaction mixture was extracted with ethyl acetate (5 mL x 4), the organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give the crude product. The crude product was used directly in the next step of the reaction without further purification (0.8 g, 89% yield). Mass spectrometry (MS) data: m/z 230 ([M-H]-).

References

[1] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 105-106