ChemicalBook > CAS DataBase List > ACK1-B19

ACK1-B19

Product Name
ACK1-B19
CAS No.
1234480-46-6
Chemical Name
ACK1-B19
Synonyms
CS-2588;XMD8-87;ACK1-B19;XMD8-87 (ACK1-B19);XMD-8-87;XMD8 87;XMD 8 87;Tyrosinase,Inhibitor,inhibit,XMD8 87,XMD-8-87,XMD887,XMD8-87;2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one;2-[[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one;5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-
CBNumber
CB92716117
Molecular Formula
C24H27N7O2
Formula Weight
445.52
MOL File
1234480-46-6.mol
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ACK1-B19 Property

Density 
1.283±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml
form 
A crystalline solid
pka
10.18±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23354
Product name
XMD8-87
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23354
Product name
XMD8-87
Purity
≥98%
Packaging
5 mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
23354
Product name
XMD8-87
Purity
≥98%
Packaging
10mg
Price
$191
Updated
2023/01/06
Tocris
Product number
6061
Product name
XMD8-87
Purity
≥98%(HPLC)
Packaging
10
Price
$183
Updated
2021/12/16
Tocris
Product number
6061
Product name
XMD8-87
Purity
≥98%(HPLC)
Packaging
50
Price
$771
Updated
2021/12/16
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ACK1-B19 Chemical Properties,Usage,Production

Description

XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and <50% inhibition for TNK2 and all other kinases tested, respectively. XMD8-87 inhibits growth of Ba/F3 cells expressing constitutively active mutant TNK2s (IC50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50 = >1 μM).

Uses

XMD8-87 is used in the studies of benzopyrimidodiazepinones as most selective and potent ERK5 inhibitor.

ACK1-B19 Preparation Products And Raw materials

Raw materials

Preparation Products

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ACK1-B19 Suppliers

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View Lastest Price from ACK1-B19 manufacturers

Career Henan Chemical Co
Product
ACK1-B19 1234480-46-6
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

1234480-46-6, ACK1-B19Related Search:

6H-PyriMido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-5,11-diMethyl- XMD17-51 XMD17 109 XMD-17-51 Trifluoroacetate 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one XMD16-5 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-5,11-dimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-, 2,2,2-trifluoroacetate (1:1) 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-, 2,2,2-trifluoroacetate (1:1)

  • ACK1-B19
  • XMD8-87
  • CS-2588
  • XMD-8-87;XMD8 87;XMD 8 87
  • 2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
  • 5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
  • 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-
  • XMD8-87 (ACK1-B19)
  • 2-((2-Methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
  • Tyrosinase,Inhibitor,inhibit,XMD8 87,XMD-8-87,XMD887,XMD8-87
  • 2-[[2-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
  • 1234480-46-6