Methyl 2-ethynylisonicotinate

Product Name: Methyl 2-ethynylisonicotinate
CAS No.: 1256810-92-0
Chemical Name: Methyl 2-ethynylisonicotinate
Synonyms: Methyl 2-ethynylisonicotinate;Methyl 2-ethynyl-4-pyridinecarboxylate;Methyl 2-ethynylisonicotinate - [M51179];4-Pyridinecarboxylic acid, 2-ethynyl-, methyl ester
CBNumber: CB92716894
Molecular Formula: C9H7NO2
Formula Weight: 161.16
MOL File: 1256810-92-0.mol

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Methyl 2-ethynylisonicotinate Property

Boiling point:: 271.1±25.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.15±0.20(Predicted)
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Synthonix

Product number: M51179
Product name: Methyl2-ethynylisonicotinate
Purity: 98%
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Synthonix

Product number: M51179
Product name: Methyl2-ethynylisonicotinate
Purity: 98%
Packaging: 250mg
Price: $170
Updated: 2021/12/16

Activate Scientific

Product number: AS44930
Product name: Methyl 2-ethynylisonicotinate
Purity: 98%
Packaging: 100mg
Price: $188
Updated: 2021/12/16

Activate Scientific

Product number: AS44930
Product name: Methyl 2-ethynylisonicotinate
Purity: 98%
Packaging: 250mg
Price: $355
Updated: 2021/12/16

Synthonix

Product number: M51179
Product name: Methyl2-ethynylisonicotinate
Purity: 98%
Packaging: 1g
Price: $420
Updated: 2021/12/16

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Methyl 2-ethynylisonicotinate Chemical Properties,Usage,Production

Synthesis

499193-51-0

1256810-92-0

Methyl 2-((trimethylsilyl)ethynyl)isonicotinate (8.00 g, 34.2 mmol) was used as the raw material, which was dissolved in THF (150 mL), and TBAF (1.0 M solution of THF, 51.4 mL, 51.4 mmol) was added slowly at 0°C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (50 mL) and washed with 10% NaHCO3 solution (50 mL). The organic layer was separated, dried with anhydrous MgSO4 and concentrated under reduced pressure to give a dark brown to black residue. The residue was loaded on silica gel and purified by column chromatography (SiO2, eluent: 0-20% ethyl acetate/petroleum ether, 40-60°C) to afford the target product methyl 2-alkynylisonicotinate (4.5 g, 81% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ 8.73 (dd, J = 5.1, 0.9 Hz, 1H), 8.01 (dd, J = 5.1, 0.9 Hz, 1H), 8.01 (dd, J = 5.1, 0.9 Hz). 8.01 (dd, J = 1.5, 0.9 Hz, 1H), 7.80 (dd, J = 5.1, 1.6 Hz, 1H), 3.95 (s, 3H), 3.22 (s, 1H).

References

[1] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 145; 146
[2] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 148

Methyl 2-ethynylisonicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 2-ethynylisonicotinate Suppliers

China 29 India 1 United States 3 Global 33

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1256810-92-0, Methyl 2-ethynylisonicotinateRelated Search:

Methyl 2-ethynylisonicotinate

4-Pyridinecarboxylic acid, 2-ethynyl-, methyl ester

Methyl 2-ethynyl-4-pyridinecarboxylate

Methyl 2-ethynylisonicotinate - [M51179]

1256810-92-0