ChemicalBook > CAS DataBase List > Ripasudil

Ripasudil

Product Name
Ripasudil
CAS No.
223645-67-8
Chemical Name
Ripasudil
Synonyms
CS-1564;Ripasudil;k115 free base;K-115, Ripasudil;RIPASUDIL HYDROCHLOIDE;RIPASUDIL FREE BASE;K 115 FREE BASE;K115 FREE BASE;(S)-4-Fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline;4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline;Isoquinoline, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-
CBNumber
CB92722374
Molecular Formula
C15H18FN3O2S
Formula Weight
323.39
MOL File
223645-67-8.mol
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Ripasudil Property

Boiling point:
497.2±55.0 °C(Predicted)
Density 
1.293±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO
pka
9.70±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

CSNpharm
Product number
CSN16953
Product name
K-115
Packaging
5mg
Price
$154
Updated
2021/12/16
Crysdot
Product number
CD31002611
Product name
K-115freebase
Purity
98+%
Packaging
250mg
Price
$515
Updated
2021/12/16
CSNpharm
Product number
CSN16953
Product name
K-115
Packaging
25mg
Price
$557
Updated
2021/12/16
Chemenu
Product number
CM146182
Product name
(S)-4-fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
Purity
98%
Packaging
100mg
Price
$880
Updated
2021/12/16
Crysdot
Product number
CD31002611
Product name
K-115freebase
Purity
98+%
Packaging
1g
Price
$1290
Updated
2021/12/16
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Ripasudil Chemical Properties,Usage,Production

Description

Ripasudil (Glanatec TM, Kowa Pharmaceutical), a close derivative of fasudil, is another Rho kinase inhibitor approved in Japan at the end of 2014 for the treatment of glaucoma and ocular hypertensionwhen other therapeutic agents are not effective or cannot be administered. Additionally, ripasudil has been tested in diabetic retinopathy clinical trials and shown to promote corneal endothelial cell proliferation, endothelium regeneration, and wound healing.

Definition

ChEBI: Ripasudil is a member of isoquinolines.

Ripasudil Preparation Products And Raw materials

Raw materials

Preparation Products

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Ripasudil Suppliers

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223645-67-8, RipasudilRelated Search:

Ripasudil hydrochloride dihydrate Ripasudil Hydrochloride CAL-101 Temsirolimus Rapamycin Icotinib Radotinib FASUDIL

  • k115 free base
  • Ripasudil
  • 4-Fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]isoquinoline
  • RIPASUDIL FREE BASE;K 115 FREE BASE;K115 FREE BASE
  • CS-1564
  • K-115, Ripasudil
  • Isoquinoline, 4-fluoro-5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-
  • RIPASUDIL HYDROCHLOIDE
  • (S)-4-Fluoro-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
  • 223645-67-8