ChemicalBook > CAS DataBase List > CDN 1163

CDN 1163

Product Name
CDN 1163
CAS No.
892711-75-0
Chemical Name
CDN 1163
Synonyms
CDN1163;4-isopropoxy-N-(2-methylquinolin-8-yl)benzamide;N-(2-methylquinolin-8-yl)-4-propan-2-yloxybenzamide;4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide;Benzamide, 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-;Inhibitor,CDN 1163,Calcium Channel,Ca channels,Ca2+ channels,CDN-1163,CDN1163,inhibit
CBNumber
CB92722925
Molecular Formula
C20H20N2O2
Formula Weight
320.39
MOL File
892711-75-0.mol
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CDN 1163 Property

Melting point:
87 - 89°C
storage temp. 
2-8°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
powder
color 
white to beige
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1682
Product name
CDN1163
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1682
Product name
CDN1163
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2023/06/20
Tocris
Product number
5869
Product name
CDN1163
Purity
≥98%(HPLC)
Packaging
10
Price
$162
Updated
2021/12/16
Tocris
Product number
5869
Product name
CDN1163
Purity
≥98%(HPLC)
Packaging
50
Price
$670
Updated
2021/12/16
TRC
Product number
M258730
Product name
4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Packaging
25mg
Price
$460
Updated
2021/12/16
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CDN 1163 Chemical Properties,Usage,Production

Description

CDN1163 (892711-75-0) is an allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).1,2? It lowered fasting glucose levels, improved glucose tolerance, and ameliorated hepatitis steatosis in ob/ob mice.1?? CDN1163 also rescued neurons from ER-stress-induced cell death in vitro and displayed significant efficacy in a rat 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease.2 It reduced age-related muscle atrophy and weakness in a C57BL/6J mice.3? CDN1163 decreased inflammatory cytokines and chemokines and attenuated mitochondrial dysfunction in Influenza A infected H1395 cells.4

Uses

4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide is an allosteric activator that increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes. 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide may have therapeutic potential for treating type-2 diabetes and metabolic dysfunction.

Definition

ChEBI: CDN1163 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-isopropoxybenzoic acid with the primary amino group of 2-methylquinolin-8-amine. An allosteric activator of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). It has a role as a SERCA activator. It is a member of quinolines, a secondary carboxamide and an aromatic ether.

Biochem/physiol Actions

CDN1163 is an allosteric activator of sarco/ endoplasmic reticulum Ca2+-ATPase (SERCA) that potently lowered fasting blood glucose, improved glucose tolerance and ameliorated hepatosteatosis in ob/ob mice. Additionally CDN1163 induces significant reduction in adipose tissue weight with no change in lean mass in ob/ob mice. CDN1163 has no effect on glucose levels or body weight in lean control mice.

storage

Store at RT

References

Kang et al. (2016), Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders; J. Biol. 291 5185 Dahl (2017), A new target for Parkinson’s disease: Small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats; Bioorg. Med. Chem. 25 53 Qaisar et al. (2020), Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice; Int. J. Mol. Sci. 22 37 Peng et al. (2021), Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells; J. Virol. 1128/JVI00217-21

CDN 1163 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDN 1163 Suppliers

China 54 United Kingdom 1 United States 8 Global 63
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Focus Biomolecules
Tel
--
Fax
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Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
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58
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Axon Medchem LLC
Tel
--
Fax
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Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58

892711-75-0, CDN 1163Related Search:

RESINIFERATOXIN N-Eicosanoyl Serotonin METHOPRENE ACID N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1)

  • N-(2-methylquinolin-8-yl)-4-propan-2-yloxybenzamide
  • 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
  • 4-isopropoxy-N-(2-methylquinolin-8-yl)benzamide
  • CDN1163
  • Benzamide, 4-(1-methylethoxy)-N-(2-methyl-8-quinolinyl)-
  • Inhibitor,CDN 1163,Calcium Channel,Ca channels,Ca2+ channels,CDN-1163,CDN1163,inhibit
  • 892711-75-0